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    araf A-Raf proto-oncogene, serine/threonine kinase [ Gadus morhua (Atlantic cod) ]

    Gene ID: 115554515, updated on 12-Sep-2024

    Summary

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    Gene symbol
    araf
    Gene description
    A-Raf proto-oncogene, serine/threonine kinase
    See related
    Ensembl:ENSGMOG00000012642
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gadus morhua
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus
    Orthologs
    zebrafish all
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    Genomic context

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    See araf in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    100 current gadMor3.0 (GCF_902167405.1) 11 NC_044058.1 (27602945..27621939)

    Chromosome 11 - NC_044058.1Genomic Context describing neighboring genes Neighboring gene RAB, member RAS oncogene family-like 6b Neighboring gene uncharacterized LOC115554539 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 4 Neighboring gene leukocyte surface antigen CD53-like Neighboring gene leukocyte surface antigen CD53-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_044058.1 Chromosome 11 Reference gadMor3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase A-Raf

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gadus morhua Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference gadMor3.0 Primary Assembly

    Genomic

    1. NC_044058.1 Reference gadMor3.0 Primary Assembly

      Range
      27602945..27621939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030371293.1 → XP_030227153.1  serine/threonine-protein kinase A-Raf isoform X1

      UniProtKB/TrEMBL
      A0A8C4ZGK9, A0A8C5B244
      Related
      ENSGMOP00000013528.2, ENSGMOT00000013885.2
      Conserved Domains (3) summary
      cd00029
      Location:104 → 149
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17133
      Location:24 → 96
      RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
      cl21453
      Location:311 → 575
      PKc_like; Protein Kinases, catalytic domain

    2. XM_030371291.1 → XP_030227151.1  serine/threonine-protein kinase A-Raf isoform X1

      UniProtKB/TrEMBL
      A0A8C4ZGK9, A0A8C5B244
      Conserved Domains (3) summary
      cd00029
      Location:104 → 149
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17133
      Location:24 → 96
      RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
      cl21453
      Location:311 → 575
      PKc_like; Protein Kinases, catalytic domain

    3. XM_030371296.1 → XP_030227156.1  serine/threonine-protein kinase A-Raf isoform X3

      UniProtKB/TrEMBL
      A0A8C5B244
      Related
      ENSGMOP00000038978.1, ENSGMOT00000038041.1
      Conserved Domains (3) summary
      cd00029
      Location:104 → 149
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17133
      Location:24 → 96
      RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
      cl21453
      Location:277 → 541
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030371295.1 → XP_030227155.1  serine/threonine-protein kinase A-Raf isoform X2

      UniProtKB/TrEMBL
      A0A8C5FEG8
      Related
      ENSGMOP00000036657.1, ENSGMOT00000031529.1
      Conserved Domains (3) summary
      cd00029
      Location:104 → 149
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17133
      Location:24 → 96
      RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
      cl21453
      Location:311 → 572
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030371292.1 → XP_030227152.1  serine/threonine-protein kinase A-Raf isoform X1

      UniProtKB/TrEMBL
      A0A8C4ZGK9, A0A8C5B244
      Conserved Domains (3) summary
      cd00029
      Location:104 → 149
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17133
      Location:24 → 96
      RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
      cl21453
      Location:311 → 575
      PKc_like; Protein Kinases, catalytic domain

    6. XM_030371294.1 → XP_030227154.1  serine/threonine-protein kinase A-Raf isoform X1

      UniProtKB/TrEMBL
      A0A8C4ZGK9, A0A8C5B244
      Conserved Domains (3) summary
      cd00029
      Location:104 → 149
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17133
      Location:24 → 96
      RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
      cl21453
      Location:311 → 575
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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