Kcnip4 Kv channel interacting protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnip4provided by MGI
Official Full Name: Kv channel interacting protein 4provided by MGI
Primary source: MGI:MGI:1933131
See related: Ensembl:ENSMUSG00000029088 AllianceGenome:MGI:1933131
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Calp; KChIP4; Calp250; KChIP4a
Summary: Enables calcium ion binding activity and potassium channel regulator activity. Involved in regulation of potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. Is expressed in brain; dorsal root ganglion; meninges; retina; and spinal cord. Orthologous to human KCNIP4 (potassium voltage-gated channel interacting protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 12.2), cortex adult (RPKM 6.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 26.26 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (48546845..49682464, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (48389503..49525122, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse.
Title: Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.
KChIP4a functions to promote tetrameric assembly and enhance surface expression of Kv4 channels.
Title: Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a.
These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a.
Title: KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.
N-terminal binding of Kv4.3 to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate.
Title: Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation.
Surface expression of Kv4 complexes may thus be controlled by an auto-inhibitory domain in the KChIP subunit.
Title: NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes.
KChIP4 was highly expressed by neurons in layers II-IV of cortex and in hippocampus, thalamus and the Purkinje cell layer of the cerebellum.
Title: Differential distribution of KChIPs mRNAs in adult mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit253 (e-PCR), detects polymorphism
- UniSTS:130388

RH125078 (e-PCR)
- UniSTS:161900

D5Mit299 (e-PCR), detects polymorphism
- UniSTS:130437

AV032399 (e-PCR)
- UniSTS:164283

Kcnip4 (e-PCR), detects polymorphism
- UniSTS:478920

Kcnip4 (e-PCR), detects polymorphism
- UniSTS:478923

Kcnip4 (e-PCR), detects polymorphism
- UniSTS:478924

Kcnip4 (e-PCR), detects polymorphism
- UniSTS:478925

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Kv channel-interacting protein 4

Names: A-type potassium channel modulatory protein 4; calsenilin-like protein; potassium channel interacting protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199242.1 → NP_001186171.1 Kv channel-interacting protein 4 isoform 1

See identical proteins and their annotated locations for NP_001186171.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1)

Source sequence(s)

AK148685, BC051130

Consensus CDS

CCDS57342.1

UniProtKB/Swiss-Prot

Q6DTJ3, Q6PHZ8, Q8CAD0, Q8R4I2, Q9EQ01

UniProtKB/TrEMBL

Q3YAA8

Related

ENSMUSP00000084656.5, ENSMUST00000087395.11

Conserved Domains (1) summary

COG5126
Location:80 → 239

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001199243.1 → NP_001186172.1 Kv channel-interacting protein 4 isoform 2

See identical proteins and their annotated locations for NP_001186172.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame 5' exon, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AK148685, BC051130, DQ148502

Consensus CDS

CCDS57341.1

UniProtKB/TrEMBL

Q3YAA7

Related

ENSMUSP00000135071.3, ENSMUST00000176191.8

Conserved Domains (1) summary

COG5126
Location:46 → 205

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001199244.1 → NP_001186173.1 Kv channel-interacting protein 4 isoform 5

See identical proteins and their annotated locations for NP_001186173.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has a distinct 5' end, compared to variant (1), which results in an isoform (5) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK148685

Consensus CDS

CCDS57340.1

UniProtKB/TrEMBL

Q3UFC0

Related

ENSMUSP00000135799.2, ENSMUST00000175660.5

Conserved Domains (1) summary

COG5126
Location:55 → 214

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001199245.1 → NP_001186174.1 Kv channel-interacting protein 4 isoform 6

See identical proteins and their annotated locations for NP_001186174.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) has a distinct 5' end, compared to variant (1), which results in an isoform (6) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK148685, DQ148504

Consensus CDS

CCDS57339.1

UniProtKB/TrEMBL

Q3YAA5

Related

ENSMUSP00000131276.2, ENSMUST00000166924.8

Conserved Domains (1) summary

COG5126
Location:63 → 222

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_030265.3 → NP_084541.3 Kv channel-interacting protein 4 isoform 4

See identical proteins and their annotated locations for NP_084541.3

Status: VALIDATED

Description

Transcript Variant: This variant (4) has a distinct 5' end, compared to variant (1), which results in an isoform (4) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK039048, AK148685

Consensus CDS

CCDS39084.1

UniProtKB/TrEMBL

Q3YAA6

Related

ENSMUSP00000134758.2, ENSMUST00000176978.8

Conserved Domains (1) summary

COG5126
Location:59 → 218

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

48546845..49682464 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165622.1 → XP_036021515.1 Kv channel-interacting protein 4 isoform X5

Conserved Domains (1) summary

COG5126
Location:29 → 188

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_036165624.1 → XP_036021517.1 Kv channel-interacting protein 4 isoform X7

UniProtKB/TrEMBL

Q3V060

Conserved Domains (1) summary

COG5126
Location:18 → 177

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_030254922.2 → XP_030110782.1 Kv channel-interacting protein 4 isoform X7

UniProtKB/TrEMBL

Q3V060

Conserved Domains (1) summary

COG5126
Location:18 → 177

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_030254920.1 → XP_030110780.1 Kv channel-interacting protein 4 isoform X4

Conserved Domains (1) summary

COG5126
Location:46 → 152

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_030254917.1 → XP_030110777.1 Kv channel-interacting protein 4 isoform X1

Conserved Domains (1) summary

COG5126
Location:80 → 186

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_030254919.1 → XP_030110779.1 Kv channel-interacting protein 4 isoform X3

Conserved Domains (1) summary

COG5126
Location:59 → 165

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_036165623.1 → XP_036021516.1 Kv channel-interacting protein 4 isoform X6

Conserved Domains (1) summary

COG5126
Location:18 → 124

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_030254921.1 → XP_030110781.1 Kv channel-interacting protein 4 isoform X6

Conserved Domains (1) summary

COG5126
Location:18 → 124

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_030254918.1 → XP_030110778.1 Kv channel-interacting protein 4 isoform X2

Conserved Domains (1) summary

COG5126
Location:63 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]