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    Llgl2 LLGL2 scribble cell polarity complex component [ Mus musculus (house mouse) ]

    Gene ID: 217325, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Llgl2provided by MGI
    Official Full Name
    LLGL2 scribble cell polarity complex componentprovided by MGI
    Primary source
    MGI:MGI:1918843
    See related
    Ensembl:ENSMUSG00000020782 AllianceGenome:MGI:1918843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Llglh2; 9130006H11Rik
    Summary
    Predicted to enable GTPase activator activity; PDZ domain binding activity; and myosin II binding activity. Acts upstream of or within establishment or maintenance of polarity of embryonic epithelium; labyrinthine layer development; and post-embryonic development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Is expressed in several structures, including cardiovascular system; endocrine gland; genitourinary system; gut; and nasal cavity epithelium. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 75.1), duodenum adult (RPKM 44.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Llgl2 in Genome Data Viewer
    Location:
    11 E2; 11 80.91 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115714855..115746606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115824029..115855780)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 94 Neighboring gene CASK-interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3039 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene STARR-seq mESC enhancer starr_31175 Neighboring gene STARR-seq mESC enhancer starr_31178 Neighboring gene myosin XVB Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115759828-115760025 Neighboring gene RecQ protein-like 5 Neighboring gene small integral membrane protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration. Dahan I, et al. Mol Biol Cell, 2012 Feb. PMID 22219375, Free PMC Article
    2. Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization. Kharfallah F, et al. Hum Mol Genet, 2017 Jun 15. PMID 28369449
    3. MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex. Weimer JM, et al. Development, 2009 Sep. PMID 19666823, Free PMC Article
    4. Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development. Sripathy S, et al. Mol Cell Biol, 2011 Jul. PMID 21606200, Free PMC Article
    5. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Klezovitch O, et al. Genes Dev, 2004 Mar 1. PMID 15037549, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27928

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of polarity of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LLGL scribble cell polarity complex component 2
    Names
    lethal giant larvae-like protein 2
    lethal(2) giant larvae protein homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252532.1 → NP_001239461.1  LLGL scribble cell polarity complex component 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the central coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) has an additional segment, compared to isoform 1.
      Source sequence(s)
      AK078901, AK143486, AY033650, BY200843
      Consensus CDS
      CCDS56820.1
      UniProtKB/TrEMBL
      J3QJU5
      Related
      ENSMUSP00000136054.2, ENSMUST00000177736.8
      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:35 → 67
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    2. NM_145438.2 → NP_663413.2  LLGL scribble cell polarity complex component 2 isoform 1

      See identical proteins and their annotated locations for NP_663413.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes a shorter isoform (1).
      Source sequence(s)
      AK078901, AK167536, BE982097, BY200843
      Consensus CDS
      CCDS25649.1
      UniProtKB/Swiss-Prot
      B1ATB0, Q3TJ91, Q6YP20, Q8K1X0
      Related
      ENSMUSP00000099321.5, ENSMUST00000103032.11
      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:35 → 67
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115714855..115746606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245894.1 → XP_030101754.1  LLGL scribble cell polarity complex component 2 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:35 → 67
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    2. XM_006533083.2 → XP_006533146.1  LLGL scribble cell polarity complex component 2 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:35 → 67
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    3. XM_006533084.2 → XP_006533147.1  LLGL scribble cell polarity complex component 2 isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:35 → 67
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    4. XM_006533085.2 → XP_006533148.1  LLGL scribble cell polarity complex component 2 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:35 → 67
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    5. XM_006533087.2 → XP_006533150.1  LLGL scribble cell polarity complex component 2 isoform X5

      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:35 → 67
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    6. XM_006533086.4 → XP_006533149.1  LLGL scribble cell polarity complex component 2 isoform X4

      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:35 → 67
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    7. XM_030245895.1 → XP_030101755.1  LLGL scribble cell polarity complex component 2 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:35 → 67
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    RNA

    1. XR_388421.2 RNA Sequence

    2. XR_388422.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TJ91.2 GenPept UniProtKB/Swiss-Prot:Q3TJ91

    Gene LinkOut

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