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    Mobp myelin-associated oligodendrocyte basic protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25037, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mobpprovided by RGD
    Official Full Name
    myelin-associated oligodendrocyte basic proteinprovided by RGD
    Primary source
    RGD:3101
    See related
    EnsemblRapid:ENSRNOG00000018700 AllianceGenome:RGD:3101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mobp81; Mobp81p
    Summary
    A structural constituent of myelin sheath. Involved in central nervous system myelin formation. Predicted to be located in mitochondrion. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in frontotemporal dementia. Orthologous to human MOBP (myelin associated oligodendrocyte basic protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 1659.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mobp in Genome Data Viewer
    Location:
    8q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128747117..128777238)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119869504..119899605)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128824420..128854492)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480248 Neighboring gene small nucleolar RNA, H/ACA box 62 Neighboring gene ribosomal protein SA Neighboring gene uncharacterized LOC102549288 Neighboring gene mitochondrial ribosome recycling factor, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene expression changes in a rat model of oxygen-induced retinopathy. Lee NE, et al. Korean J Ophthalmol, 2011 Feb. PMID 21350694, Free PMC Article
    2. Developmental expression of the myelin gene MOBP in the rat nervous system. Holz A, et al. J Neurocytol, 1997 Jul. PMID 9306245
    3. Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis. Holz A, et al. J Immunol, 2000 Jan 15. PMID 10623862
    4. Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia. Irwin DJ, et al. Neurology, 2014 Aug 5. PMID 24994843, Free PMC Article
    5. Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin. Yamamoto Y, et al. J Biol Chem, 1994 Dec 16. PMID 7989345

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105491

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system myelin formation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myelin-associated oligodendrocyte basic protein
    Names
    Myelin-associated/Oligodendrocytic Basic Protein-81
    RNMOBP81P
    myelin-associated oligodendrocytic basic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389272.1 → NP_001376201.1  myelin-associated oligodendrocyte basic protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
      UniProtKB/TrEMBL
      B1WBR5
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    2. NM_001389273.1 → NP_001376202.1  myelin-associated oligodendrocyte basic protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
      UniProtKB/TrEMBL
      B1WBR5
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    3. NM_012720.2 → NP_036852.1  myelin-associated oligodendrocyte basic protein isoform 1

      See identical proteins and their annotated locations for NP_036852.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I401
      Conserved Domains (1) summary
      cl22851
      Location:1 → 67
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      128747117..128777238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080858.2 → XP_038936786.1  myelin-associated oligodendrocyte basic protein isoform X1

      UniProtKB/Swiss-Prot
      Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
      UniProtKB/TrEMBL
      B1WBR5
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    2. XM_039080854.2 → XP_038936782.1  myelin-associated oligodendrocyte basic protein isoform X1

      UniProtKB/Swiss-Prot
      Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
      UniProtKB/TrEMBL
      B1WBR5
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    3. XM_039080855.2 → XP_038936783.1  myelin-associated oligodendrocyte basic protein isoform X1

      UniProtKB/Swiss-Prot
      Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
      UniProtKB/TrEMBL
      B1WBR5
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    4. XM_039080856.2 → XP_038936784.1  myelin-associated oligodendrocyte basic protein isoform X1

      UniProtKB/Swiss-Prot
      Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
      UniProtKB/TrEMBL
      B1WBR5
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    5. XM_039080860.2 → XP_038936788.1  myelin-associated oligodendrocyte basic protein isoform X2

      UniProtKB/TrEMBL
      A6I402
      Related
      ENSRNOP00000112149.1, ENSRNOT00000130926.1
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    6. XM_039080862.2 → XP_038936790.1  myelin-associated oligodendrocyte basic protein isoform X3

      UniProtKB/TrEMBL
      A6I401
      Conserved Domains (1) summary
      cl22851
      Location:1 → 67
      PHD_SF; PHD finger superfamily

    7. XM_039080859.1 → XP_038936787.1  myelin-associated oligodendrocyte basic protein isoform X1

      UniProtKB/Swiss-Prot
      Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
      UniProtKB/TrEMBL
      B1WBR5
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    8. XM_063264939.1 → XP_063121009.1  myelin-associated oligodendrocyte basic protein isoform X2

      UniProtKB/TrEMBL
      A6I402

    9. XM_039080863.2 → XP_038936791.1  myelin-associated oligodendrocyte basic protein isoform X3

      UniProtKB/TrEMBL
      A6I401
      Conserved Domains (1) summary
      cl22851
      Location:1 → 67
      PHD_SF; PHD finger superfamily

    10. XM_039080857.2 → XP_038936785.1  myelin-associated oligodendrocyte basic protein isoform X1

      UniProtKB/Swiss-Prot
      Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
      UniProtKB/TrEMBL
      B1WBR5
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    11. XM_039080861.1 → XP_038936789.1  myelin-associated oligodendrocyte basic protein isoform X2

      UniProtKB/TrEMBL
      A6I402
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    12. XM_063264940.1 → XP_063121010.1  myelin-associated oligodendrocyte basic protein isoform X3

      UniProtKB/TrEMBL
      A6I401
      Related
      ENSRNOP00000105313.1, ENSRNOT00000148240.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63327.1 GenPept UniProtKB/Swiss-Prot:Q63327

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