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    PECAM1 platelet and endothelial cell adhesion molecule 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282303, updated on 4-Oct-2024

    Summary

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    Official Symbol
    PECAM1provided by VGNC
    Official Full Name
    platelet and endothelial cell adhesion molecule 1provided by VGNC
    Primary source
    VGNC:VGNC:32737
    See related
    BGD:BT11556; Ensembl:ENSBTAG00000012066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PECAM1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (48525295..48619385, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343102 Neighboring gene testis expressed 2 Neighboring gene uncharacterized LOC132343101 Neighboring gene uncharacterized LOC112442686 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene DNA polymerase gamma 2, accessory subunit Neighboring gene microRNA mir-3064 Neighboring gene DEAD-box helicase 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PECAM-1 is involved in neutrophil transmigration across Histophilus somni treated bovine brain endothelial cells. Tiwari R, et al. Microb Pathog, 2009 Sep. PMID 19524660
    2. Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells. Osawa M, et al. Eur J Cell Biol, 1997 Mar. PMID 9084985
    3. Vascular endothelial platelet endothelial adhesion molecule-1 (PECAM-1) expression is decreased by TNF-alpha and IFN-gamma. Evidence for cytokine-induced destabilization of messenger ribonucleic acid transcripts in bovine endothelial cells. Stewart RJ, et al. J Immunol, 1996 Feb 1. PMID 8558001
    4. Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Collins C, et al. Curr Biol, 2012 Nov 20. PMID 23084990, Free PMC Article
    5. MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells. Sumpio BE, et al. J Biol Chem, 2005 Mar 25. PMID 15668248

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This work provides the first evidence of a global signaling event in response to a localized mechanical stress.
      Title: Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway.
    2. novel pathway for PECAM-1 regulation
      Title: A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis.
    3. PECAM-1 plays a role in the early pathogenesis of thrombotic meningoencephalitis.
      Title: PECAM-1 is involved in neutrophil transmigration across Histophilus somni treated bovine brain endothelial cells.
    4. PECAM-1 and Fyn are essential components of a PECAM-1-based mechanosensory complex in endothelial cells
      Title: Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation.
    5. PECAM-1 may not function as a major mechanoreceptor for activation of MAPK and AKT in ECs and that there are likely to be other mechanoreceptors in ECs functioning to detect shear stress and trigger intercellular signals.
      Title: MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140603

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet endothelial cell adhesion molecule
    Names
    CD31 antigen
    PECAM-1
    platelet/endothelial cell adhesion molecule (CD31 antigen)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174571.3 → NP_776996.2  platelet endothelial cell adhesion molecule precursor

      See identical proteins and their annotated locations for NP_776996.2

      Status: VALIDATED

      Source sequence(s)
      BC120068, BE754205, EE921094, EH155341
      UniProtKB/TrEMBL
      P79390, Q0VCP8
      Related
      ENSBTAP00000101210.1, ENSBTAT00000121091.1
      Conserved Domains (3) summary
      smart00410
      Location:511 → 591
      IG_like; Immunoglobulin like
      pfam13895
      Location:327 → 404
      Ig_2; Immunoglobulin domain
      cl11960
      Location:43 → 121
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48525295..48619385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005221005.5 → XP_005221062.3  platelet endothelial cell adhesion molecule isoform X3

      UniProtKB/TrEMBL
      P79390
      Related
      ENSBTAP00000068562.2, ENSBTAT00000086833.2
      Conserved Domains (3) summary
      smart00410
      Location:511 → 591
      IG_like; Immunoglobulin like
      pfam13895
      Location:327 → 404
      Ig_2; Immunoglobulin domain
      cl11960
      Location:43 → 121
      Ig; Immunoglobulin domain

    2. XM_005221002.5 → XP_005221059.3  platelet endothelial cell adhesion molecule isoform X5

      UniProtKB/TrEMBL
      P79390
      Conserved Domains (3) summary
      smart00410
      Location:511 → 591
      IG_like; Immunoglobulin like
      pfam13895
      Location:327 → 404
      Ig_2; Immunoglobulin domain
      cl11960
      Location:43 → 121
      Ig; Immunoglobulin domain

    3. XM_015458920.3 → XP_015314406.2  platelet endothelial cell adhesion molecule isoform X5

      UniProtKB/TrEMBL
      P79390
      Conserved Domains (3) summary
      smart00410
      Location:511 → 591
      IG_like; Immunoglobulin like
      pfam13895
      Location:327 → 404
      Ig_2; Immunoglobulin domain
      cl11960
      Location:43 → 121
      Ig; Immunoglobulin domain

    4. XM_005221004.5 → XP_005221061.3  platelet endothelial cell adhesion molecule isoform X2

      UniProtKB/TrEMBL
      P79390
      Conserved Domains (3) summary
      smart00410
      Location:511 → 591
      IG_like; Immunoglobulin like
      pfam13895
      Location:327 → 404
      Ig_2; Immunoglobulin domain
      cl11960
      Location:43 → 121
      Ig; Immunoglobulin domain

    5. XM_005221006.5 → XP_005221063.3  platelet endothelial cell adhesion molecule isoform X4

      UniProtKB/TrEMBL
      P79390
      Conserved Domains (3) summary
      smart00410
      Location:511 → 591
      IG_like; Immunoglobulin like
      pfam13895
      Location:327 → 404
      Ig_2; Immunoglobulin domain
      cl11960
      Location:43 → 121
      Ig; Immunoglobulin domain

    6. XM_005221003.5 → XP_005221060.3  platelet endothelial cell adhesion molecule isoform X1

      UniProtKB/TrEMBL
      P79390
      Related
      ENSBTAP00000081163.1, ENSBTAT00000114554.1
      Conserved Domains (3) summary
      smart00410
      Location:511 → 591
      IG_like; Immunoglobulin like
      pfam13895
      Location:327 → 404
      Ig_2; Immunoglobulin domain
      cl11960
      Location:43 → 121
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51866.1 GenPept UniProtKB/Swiss-Prot:P51866

    Gene LinkOut

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    Research Materials