DNAJB3 DnaJ heat shock protein family (Hsp40) member B3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DNAJB3provided by HGNC
Official Full Name: DnaJ heat shock protein family (Hsp40) member B3provided by HGNC
Primary source: HGNC:HGNC:32397
See related: Ensembl:ENSG00000293135 AllianceGenome:HGNC:32397
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HCG3
Summary: Predicted to enable Hsp70 protein binding activity and unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be located in acrosomal vesicle and centrosome. [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: 2q37.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (233742750..233743998, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (234231381..234232629, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (234651396..234652644, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation.
Title: DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation.
Single nucleotide polymorphism in DNAJB3 gene is associated with Systemic lupus erythematosus
Title: Novel linkage disequilibrium clustering algorithm identifies new lupus genes on meta-analysis of GWAS datasets.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD05707 (e-PCR)
- UniSTS:286769

ECD04933 (e-PCR)
- UniSTS:286003

ECD07800 (e-PCR)
- UniSTS:288850

REN46026 (e-PCR)
- UniSTS:370826

REN46027 (e-PCR)
- UniSTS:370827

REN46064 (e-PCR)
- UniSTS:370864

REN46065 (e-PCR)
- UniSTS:370865

REN46066 (e-PCR)
- UniSTS:370866

REN46067 (e-PCR)
- UniSTS:370867

REN46068 (e-PCR)
- UniSTS:370868

REN46069 (e-PCR)
- UniSTS:370869

REN46070 (e-PCR)
- UniSTS:370870

REN46071 (e-PCR)
- UniSTS:370871

REN46072 (e-PCR)
- UniSTS:370872

REN46073 (e-PCR)
- UniSTS:370873

REN46074 (e-PCR)
- UniSTS:370874

REN46075 (e-PCR)
- UniSTS:370875

ECD04094 (e-PCR)
- UniSTS:285173

Other Names

DnaJ (Hsp40) homolog, subfamily B, member 3
dnaJ homolog subfamily B member 3

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.