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    Gprc5d G protein-coupled receptor, family C, group 5, member D [ Mus musculus (house mouse) ]

    Gene ID: 93746, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gprc5dprovided by MGI
    Official Full Name
    G protein-coupled receptor, family C, group 5, member Dprovided by MGI
    Primary source
    MGI:MGI:1935037
    See related
    Ensembl:ENSMUSG00000030205 AllianceGenome:MGI:1935037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein kinase activator activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and respiratory system. Orthologous to human GPRC5D (G protein-coupled receptor class C group 5 member D). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Gprc5d in Genome Data Viewer
    Location:
    6 G1; 6 65.89 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135082989..135095281, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135105991..135118283, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E865 Neighboring gene DEAD box helicase 47 Neighboring gene STARR-seq mESC enhancer starr_17562 Neighboring gene G protein-coupled receptor, family C, group 5, member A Neighboring gene Hebp1R1 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_17563 Neighboring gene fucose mutarotase-like Neighboring gene Hebp1R3 erythroid cis-regulatory module Neighboring gene heme binding protein 1 Neighboring gene predicted gene, 22881

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RAIG family member, GPRC5D, is associated with hard-keratinized structures. Inoue S, et al. J Invest Dermatol, 2004 Mar. PMID 15086536
    2. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Bräuner-Osborne H, et al. Biochim Biophys Acta, 2001 Apr 16. PMID 11311935
    3. Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression. Xu J, et al. Am J Respir Cell Mol Biol, 2005 May. PMID 15677768
    4. Gpr158 mediates osteocalcin's regulation of cognition. Khrimian L, et al. J Exp Med, 2017 Oct 2. PMID 28851741, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPRC5D is involed in the regulation of keratin synthesis in hard epithelial tissue.
      Title: The RAIG family member, GPRC5D, is associated with hard-keratinized structures.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in hair cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in keratinization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular exosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor family C group 5 member D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205396.1 → NP_001192325.1  G-protein coupled receptor family C group 5 member D isoform 1

      See identical proteins and their annotated locations for NP_001192325.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131718, AF218809, AK137739
      Consensus CDS
      CCDS57462.1
      UniProtKB/Swiss-Prot
      Q8CJI0, Q8CJI1, Q9JIL6
      UniProtKB/TrEMBL
      Q3UUY8
      Related
      ENSMUSP00000032327.8, ENSMUST00000032327.14
      Conserved Domains (1) summary
      cd15279
      Location:21 → 267
      7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D

    2. NM_053118.1 → NP_444348.1  G-protein coupled receptor family C group 5 member D isoform 2

      See identical proteins and their annotated locations for NP_444348.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF218809
      Consensus CDS
      CCDS39680.1
      UniProtKB/TrEMBL
      Q0VEL2
      Related
      ENSMUSP00000107553.2, ENSMUST00000111922.2
      Conserved Domains (1) summary
      pfam00003
      Location:61 → 264
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      135082989..135095281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIL6.2 GenPept UniProtKB/Swiss-Prot:Q9JIL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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