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    Lekr1 leucine, glutamate and lysine rich 1 [ Mus musculus (house mouse) ]

    Gene ID: 624866, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lekr1provided by MGI
    Official Full Name
    leucine, glutamate and lysine rich 1provided by MGI
    Primary source
    MGI:MGI:3645902
    See related
    Ensembl:ENSMUSG00000074579 AllianceGenome:MGI:3645902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm6534; EG546798; EG624866
    Summary
    Orthologous to human LEKR1 (leucine, glutamate and lysine rich 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 1.2), CNS E18 (RPKM 0.7) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lekr1 in Genome Data Viewer
    Location:
    3 E1; 3 30.24 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (65566960..65743948)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (65659539..65836527)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_07866 Neighboring gene STARR-seq mESC enhancer starr_07867 Neighboring gene STARR-positive B cell enhancer ABC_E11189 Neighboring gene predicted gene, 54197 Neighboring gene microRNA 8120 Neighboring gene STARR-seq mESC enhancer starr_07869 Neighboring gene STARR-seq mESC enhancer starr_07870 Neighboring gene predicted gene, 25755 Neighboring gene predicted gene, 54198 Neighboring gene STARR-positive B cell enhancer ABC_E9008 Neighboring gene predicted gene, 35039

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of cell-type-specific gene expression during mouse spermatogenesis. Almstrup K, et al. Biol Reprod, 2004 Jun. PMID 14960480
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein LEKR1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037923.4 → NP_001033012.2  protein LEKR1 isoform 2

      See identical proteins and their annotated locations for NP_001033012.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC114650, AK137452, BB373830, CJ137734
      Consensus CDS
      CCDS17389.1
      UniProtKB/TrEMBL
      B2RVN1, Q3UVB4
      Related
      ENSMUSP00000096674.3, ENSMUST00000099075.4
      Conserved Domains (1) summary
      pfam10498
      Location:33 → 85
      IFT57; Intra-flagellar transport protein 57

    2. NM_001166659.1 → NP_001160131.1  protein LEKR1 isoform 1

      See identical proteins and their annotated locations for NP_001160131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the full-length isoform (1). The exon combination of this variant is predicted based on orthologous transcript alignments.
      Source sequence(s)
      AC110245, AC114650
      UniProtKB/TrEMBL
      A0A571BF98
      Related
      ENSMUSP00000158835.2, ENSMUST00000177434.3
      Conserved Domains (1) summary
      COG1196
      Location:260 → 591
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      65566960..65743948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501847.3 → XP_006501910.1  protein LEKR1 isoform X3

      See identical proteins and their annotated locations for XP_006501910.1

      UniProtKB/TrEMBL
      A0A571BF98
      Conserved Domains (1) summary
      COG1196
      Location:260 → 591
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006501844.2 → XP_006501907.1  protein LEKR1 isoform X1

      See identical proteins and their annotated locations for XP_006501907.1

      Conserved Domains (1) summary
      COG1196
      Location:71 → 402
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_011240186.3 → XP_011238488.1  protein LEKR1 isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:106 → 395
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version

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