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    Tbc1d14 TBC1 domain family, member 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360956, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tbc1d14provided by RGD
    Official Full Name
    TBC1 domain family, member 14provided by RGD
    Primary source
    RGD:1309993
    See related
    EnsemblRapid:ENSRNOG00000006400 AllianceGenome:RGD:1309993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SRF-2; UR-NR#2
    Summary
    Predicted to enable GTPase activator activity and protein kinase binding activity. Predicted to be involved in negative regulation of autophagy; recycling endosome to Golgi transport; and regulation of autophagosome assembly. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in autophagosome and recycling endosome. Orthologous to human TBC1D14 (TBC1 domain family member 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 104.6), Adrenal (RPKM 70.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d14 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (78397345..78496863)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (74172652..74272182)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (79172272..79438765)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693769 Neighboring gene KIAA0232 homolog Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120096639 Neighboring gene selenoprotein K, pseudogene 3 Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene coiled-coil domain containing 96

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel spermatogenesis related factor-2 (SRF-2) gene expression affected by TCDD treatment. Yamano Y, et al. Endocr J, 2005 Feb. PMID 15758561
    2. Gene expression variance based on random sequencing in rat remnant kidney. Horiba N, et al. Kidney Int, 2004 Jul. PMID 15200410
    3. TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. Longatti A, et al. J Cell Biol, 2012 May 28. PMID 22613832, Free PMC Article
    4. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Fuchs E, et al. J Cell Biol, 2007 Jun 18. PMID 17562788, Free PMC Article
    5. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124676

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in recycling endosome to Golgi transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in recycling endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 14
    Names
    Up-regulated in nephrectomized rat kidney #2
    spermatogenesis-related factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012152.2 → NP_001012152.2  TBC1 domain family member 14 isoform 1

      See identical proteins and their annotated locations for NP_001012152.2

      Status: VALIDATED

      Source sequence(s)
      BC099760, BC107659
      UniProtKB/TrEMBL
      A0A0G2K2K3
      Related
      ENSRNOP00000072277.1, ENSRNOT00000082704.3
      Conserved Domains (1) summary
      smart00164
      Location:118 → 350
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. NM_001034021.2 → NP_001029193.2  TBC1 domain family member 14 isoform 2

      See identical proteins and their annotated locations for NP_001029193.2

      Status: VALIDATED

      Source sequence(s)
      BC099760, CB746983
      UniProtKB/Swiss-Prot
      Q499U3, Q5CD77, Q6I7R4
      Conserved Domains (2) summary
      smart00164
      Location:399 → 631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam13904
      Location:127 → 364
      DUF4207; Domain of unknown function (DUF4207)

    3. NM_001113365.1 → NP_001106836.1  TBC1 domain family member 14 isoform 3

      See identical proteins and their annotated locations for NP_001106836.1

      Status: VALIDATED

      Source sequence(s)
      AB117752, BC099760
      UniProtKB/TrEMBL
      A0A0G2K7D5, A6IJY0, G3V9P9
      Related
      ENSRNOP00000055215.2, ENSRNOT00000058414.5
      Conserved Domains (2) summary
      smart00164
      Location:419 → 651
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam13904
      Location:147 → 384
      DUF4207; Domain of unknown function (DUF4207)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      78397345..78496863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273358.1 → XP_063129428.1  TBC1 domain family member 14 isoform X1

      UniProtKB/TrEMBL
      A6IJY0, G3V9P9

    2. XM_039092194.2 → XP_038948122.1  TBC1 domain family member 14 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K7D5
      Related
      ENSRNOP00000081599.1, ENSRNOT00000094036.2
      Conserved Domains (1) summary
      smart00164
      Location:419 → 627
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    3. XM_006251133.5 → XP_006251195.1  TBC1 domain family member 14 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7D5
      Related
      ENSRNOP00000075351.2, ENSRNOT00000085534.3
      Conserved Domains (2) summary
      smart00164
      Location:419 → 607
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam13904
      Location:147 → 384
      DUF4207; Domain of unknown function (DUF4207)

    4. XM_006251134.5 → XP_006251196.1  TBC1 domain family member 14 isoform X2

      See identical proteins and their annotated locations for XP_006251196.1

      UniProtKB/Swiss-Prot
      Q499U3, Q5CD77, Q6I7R4
      Related
      ENSRNOP00000101690.1, ENSRNOT00000141059.1
      Conserved Domains (2) summary
      smart00164
      Location:399 → 631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam13904
      Location:127 → 364
      DUF4207; Domain of unknown function (DUF4207)

    5. XM_063273359.1 → XP_063129429.1  TBC1 domain family member 14 isoform X4

      Related
      ENSRNOP00000074160.3, ENSRNOT00000077846.3

    6. XM_008770325.4 → XP_008768547.1  TBC1 domain family member 14 isoform X7

      See identical proteins and their annotated locations for XP_008768547.1

      Conserved Domains (1) summary
      smart00164
      Location:58 → 290
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    7. XM_063273360.1 → XP_063129430.1  TBC1 domain family member 14 isoform X6

    8. XM_008770326.4 → XP_008768548.1  TBC1 domain family member 14 isoform X7

      See identical proteins and their annotated locations for XP_008768548.1

      Conserved Domains (1) summary
      smart00164
      Location:58 → 290
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5CD77.2 GenPept UniProtKB/Swiss-Prot:Q5CD77

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