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    mrcA peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947907, updated on 19-Sep-2024

    Summary

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    Official Symbol
    mrcA
    Official Full Name
    peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcA
    Primary source
    ECOCYC:EG10748
    Locus tag
    b3396
    See related
    ASAP:ABE-0011082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3383; ponA
    Summary
    The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. [More information is available at EcoGene: EG10748]. PBP1A, the product of the mrcA gene, is a bifunctional, inner membrane enzyme catalyzing the transglycosylation and transpeptidation of murein (peptidoglycan) precursors in the formation of the murein sacculus. [More information is available at EcoCyc: EG10748].
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    Genomic context

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    Sequence:
    NC_000913.3 (3522871..3525423)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA utilization protein HofO Neighboring gene DNA utilization protein HofN Neighboring gene DNA utilization protein HofM Neighboring gene ADP-sugar diphosphatase NudE Neighboring gene inner membrane protein IgaA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of bacteriolysis by cooperative effects of penicillin-binding proteins 1a and 3 in Escherichia coli. Tuomanen E, et al. Antimicrob Agents Chemother, 1986 Nov. PMID 3541782, Free PMC Article
    2. Hybrid proteins of the transglycosylase and the transpeptidase domains of PBP1B and PBP3 of Escherichia coli. Zijderveld CA, et al. J Bacteriol, 1995 Nov. PMID 7592397, Free PMC Article
    3. Lysis of Escherichia coli by beta-lactams which bind penicillin-binding proteins 1a and 1b: inhibition by heat shock proteins. Powell JK, et al. J Bacteriol, 1991 Jul. PMID 2061284, Free PMC Article
    4. Dual enzyme activities of cell wall peptidoglycan synthesis, peptidoglycan transglycosylase and penicillin-sensitive transpeptidase, in purified preparations of Escherichia coli penicillin-binding protein 1A. Ishino F, et al. Biochem Biophys Res Commun, 1980 Nov 17. PMID 7006606
    5. Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. Barrett D, et al. J Biol Chem, 2007 Nov 2. PMID 17704540, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that outer-membrane-anchored lipoprotein LpoA has an elongated molecular shape, with dimensions sufficient to span from the outer membrane through the periplasm to interact with the peptidoglycan synthase PBP1A.
      Title: Elongated structure of the outer-membrane activator of peptidoglycan synthesis LpoA: implications for PBP1A stimulation.
    2. analysis of synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli
      Title: In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables penicillin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables penicillin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidoglycan glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan glycosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type D-Ala-D-Ala carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type D-Ala-D-Ala carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type carboxypeptidase activity RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell shape NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3522871..3525423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417855.4 peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417855.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M182, A0A5B9AND5, A0A8S7I2A8
      Conserved Domains (1) summary
      PRK11636
      Location:1 → 850
      mrcA; penicillin-binding protein 1a; Provisional
    Nucleotide Protein
    Heading Accession and Version

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