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    iraP anti-adaptor protein IraP [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947709, updated on 10-Oct-2024

    Summary

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    Official Symbol
    iraP
    Official Full Name
    anti-adaptor protein IraP
    Primary source
    ECOCYC:EG11256
    Locus tag
    b0382
    See related
    ASAP:ABE-0001313
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0377; yaiB
    Summary
    IraP interferes with RssB, ClpXP-dependent degradation of RpoS by interacting directly with RssB. [More information is available at EcoGene: EG11256]. IraP is an anti-adaptor protein that is required for stabilization of the alternative sigma factor S during phosphate starvation and plays a role in stationary phase and nitrogen starvation. [More information is available at EcoCyc: EG11256].
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    Genomic context

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    Sequence:
    NC_000913.3 (401386..401646)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2754 domain-containing protein YaiZ Neighboring gene D-alanine--D-alanine ligase A Neighboring gene alkaline phosphatase Neighboring gene phosphate starvation-inducible protein PsiF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica. Tu X, et al. Proc Natl Acad Sci U S A, 2006 Sep 5. PMID 16938894, Free PMC Article
    2. The molecular evolution of bacterial alkaline phosphatase: correlating variation among enteric bacteria to experimental manipulations of the protein. DuBose RF, et al. Mol Biol Evol, 1990 Nov. PMID 2129542
    3. The nucleotide sequence of the promoter and the amino-terminal region of alkaline phosphatase structural gene (phoA) of Escherichia coli. Kikuchi Y, et al. Nucleic Acids Res, 1981 Nov 11. PMID 6273802, Free PMC Article
    4. Biofilm formation-gene expression relay system in Escherichia coli: modulation of sigmaS-dependent gene expression by the CsgD regulatory protein via sigmaS protein stabilization. Gualdi L, et al. J Bacteriol, 2007 Nov. PMID 17873038, Free PMC Article
    5. Modulating RssB activity: IraP, a novel regulator of sigma(S) stability in Escherichia coli. Bougdour A, et al. Genes Dev, 2006 Apr 1. PMID 16600914, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables anti-sigma factor antagonist activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anti-adaptor protein IraP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      401386..401646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414916.1 anti-adaptor protein IraP [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414916.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A793I168, A0AAQ2LVF0
      Conserved Domains (1) summary
      PRK10244
      Location:1 → 86
      PRK10244; anti-adapter protein IraP
    Nucleotide Protein
    Heading Accession and Version

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