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    Mfap2 microfibrillar-associated protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 17150, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mfap2provided by MGI
    Official Full Name
    microfibrillar-associated protein 2provided by MGI
    Primary source
    MGI:MGI:99559
    See related
    Ensembl:ENSMUSG00000060572 AllianceGenome:MGI:99559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Magp; Magp1; MAGP-1; MFAP-2
    Summary
    Enables fibrinogen binding activity and fibronectin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within platelet formation. Located in microfibril. Is expressed in several structures, including brain; embryo mesenchyme; eye; genitourinary system; and lung. Orthologous to human MFAP2 (microfibril associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 107.3), ovary adult (RPKM 71.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mfap2 in Genome Data Viewer
    Location:
    4 D3; 4 73.31 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140737735..140743284)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141010424..141015976)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11883 Neighboring gene STARR-positive B cell enhancer ABC_E10271 Neighboring gene succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Neighboring gene STARR-positive B cell enhancer ABC_E6248 Neighboring gene ATPase type 13A2 Neighboring gene ciliary rootlet coiled-coil, rootletin Neighboring gene STARR-seq mESC enhancer starr_11885 Neighboring gene STARR-positive B cell enhancer ABC_E4695 Neighboring gene STARR-positive B cell enhancer ABC_E10272 Neighboring gene STARR-positive B cell enhancer ABC_E3532 Neighboring gene NECAP endocytosis associated 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MFAP2 promotes HSCs activation through FBN1/TGF-β/Smad3 pathway. Sun Y, et al. J Cell Mol Med, 2023 Nov. PMID 37635348, Free PMC Article
    2. Structure, chromosomal localization, and expression pattern of the murine Magp gene. Chen Y, et al. J Biol Chem, 1993 Dec 25. PMID 8262979
    3. Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells. Segade F, et al. Biochim Biophys Acta, 2005 Dec 20. PMID 16321658
    4. Microfibril-Associated Protein 2 (MFAP2) Potentiates Invasion and Migration of Melanoma by EMT and Wnt/β-Catenin Pathway. Chen Z, et al. Med Sci Monit, 2020 May 28. PMID 32464633, Free PMC Article
    5. Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. Weinbaum JS, et al. J Biol Chem, 2008 Sep 12. PMID 18625713, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MFAP2 promotes HSCs activation through FBN1/TGF-beta/Smad3 pathway.
      Title: MFAP2 promotes HSCs activation through FBN1/TGF-β/Smad3 pathway.
    2. MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
      Title: MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
    3. Microfibril-Associated Protein 2 (MFAP2) Potentiates Invasion and Migration of Melanoma by EMT and Wnt/beta-Catenin Pathway.
      Title: Microfibril-Associated Protein 2 (MFAP2) Potentiates Invasion and Migration of Melanoma by EMT and Wnt/β-Catenin Pathway.
    4. Data implicate systemic metabolic dysfunction in the development of bone fragility in germline Mfap2(-/-) mice. Also, MAGP1 protein was detected in the Mfap2(Prx-/-) hematopoietic bone marrow, despite of its absence in osseous bone matrix and its transcript at both sites. This suggests MAGP1 from a secondary site may accumulate in the bone marrow, but not into the bone matrix, during times of regional MAGP1 depletion.
      Title: Contribution of metabolic disease to bone fragility in MAGP1-deficient mice.
    5. Findings indicate that the regulation of TGF-beta by MAGP1 is protective against the effects of metabolic stress, and its absence predisposes individuals to metabolic dysfunction.
      Title: The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β.
    6. These studies provide support for increased RANKL expression associated with MAGP1 deficiency and provide a link to altered TGF-beta signaling as a possible causative signaling pathway regulating RANKL expression in MAGP1-deficient osteoblasts.
      Title: Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.
    7. MAGP1 is a regulator of bone remodeling, and its absence results in osteopenia associated with an increase in osteoclast number
      Title: Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling.
    8. microfibril-associated glycoprotein-1 has a role in complex phenotypes in multiple organ systems
      Title: Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.
    9. These findings show that MAGP1, a component of microfibrils and vascular elastic fibers, plays a role in hemostasis and thrombosis.
      Title: Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.
    10. Site-directed and random mutagenesis demonstrated that a KLF sequence motif at -256/-270, an E-box at -222/-229, and a GC-box at -117/-125, are critical for the promoter function.
      Title: Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables fibrinogen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fibronectin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic eye morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within platelet formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microfibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microfibril IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microfibrillar-associated protein 2
    Names
    microfibril-associated glycoprotein 1
    microfibril-associated glycoprotein 1A
    microfibril-associated glycoprotein 1D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161799.3 → NP_001155271.2  microfibrillar-associated protein 2 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AL645625
      Consensus CDS
      CCDS18860.2
      UniProtKB/Swiss-Prot
      P55002
      UniProtKB/TrEMBL
      Q99PM0
      Related
      ENSMUSP00000132711.4, ENSMUST00000166376.10
      Conserved Domains (1) summary
      pfam05507
      Location:91 → 151
      MAGP; Microfibril-associated glycoprotein (MAGP)

    2. NM_001369292.2 → NP_001356221.1  microfibrillar-associated protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL645625
      Conserved Domains (1) summary
      pfam05507
      Location:81 → 141
      MAGP; Microfibril-associated glycoprotein (MAGP)

    3. NM_001421243.2 → NP_001408172.2  microfibrillar-associated protein 2 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AL645625
      UniProtKB/Swiss-Prot
      P55002

    4. NM_008546.5 → NP_032572.3  microfibrillar-associated protein 2 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AL645625
      Consensus CDS
      CCDS18860.2
      UniProtKB/Swiss-Prot
      P55002
      UniProtKB/TrEMBL
      Q99PM0
      Related
      ENSMUSP00000071868.10, ENSMUST00000071977.10
      Conserved Domains (1) summary
      pfam05507
      Location:91 → 151
      MAGP; Microfibril-associated glycoprotein (MAGP)

    RNA

    1. NR_161285.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645625

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      140737735..140743284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538614.5 → XP_006538677.1  microfibrillar-associated protein 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55002.1 GenPept UniProtKB/Swiss-Prot:P55002

    Gene LinkOut

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