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    Tmem143 transmembrane protein 143 [ Mus musculus (house mouse) ]

    Gene ID: 70209, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem143provided by MGI
    Official Full Name
    transmembrane protein 143provided by MGI
    Primary source
    MGI:MGI:1917459
    See related
    Ensembl:ENSMUSG00000002781 AllianceGenome:MGI:1917459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310076O21Rik
    Summary
    Acts upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. Orthologous to human TMEM143 (transmembrane protein 143). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 68.2), heart adult (RPKM 64.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem143 in Genome Data Viewer
    Location:
    7 B3; 7 29.58 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45546403..45566837)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45896991..45917413)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 Neighboring gene synaptogyrin 4 Neighboring gene STARR-positive B cell enhancer ABC_E1087 Neighboring gene STARR-positive B cell enhancer ABC_E8172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:53178126-53178235 Neighboring gene STARR-positive B cell enhancer ABC_E6547 Neighboring gene STARR-positive B cell enhancer ABC_E873 Neighboring gene epithelial membrane protein 3 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 143

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144801.2 → NP_659050.2  transmembrane protein 143

      See identical proteins and their annotated locations for NP_659050.2

      Status: VALIDATED

      Source sequence(s)
      AK039173, AK087636, BB666121, BB739600, BE946904
      Consensus CDS
      CCDS21269.1
      UniProtKB/Swiss-Prot
      Q8BHU3, Q8BI00, Q8BI09, Q8VD26
      UniProtKB/TrEMBL
      G3X9F4
      Related
      ENSMUSP00000070405.8, ENSMUST00000069772.16
      Conserved Domains (1) summary
      pfam12576
      Location:226 → 348
      DUF3754; Protein of unknown function (DUF3754)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45546403..45566837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541188.4 → XP_006541251.1  transmembrane protein 143 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHU3, Q8BI00, Q8BI09, Q8VD26
      Conserved Domains (1) summary
      pfam12576
      Location:191 → 313
      DUF3754; Protein of unknown function (DUF3754)

    2. XM_006541189.4 → XP_006541252.1  transmembrane protein 143 isoform X2

      Conserved Domains (1) summary
      pfam12576
      Location:119 → 241
      DUF3754; Protein of unknown function (DUF3754)

    3. XM_036153430.1 → XP_036009323.1  transmembrane protein 143 isoform X3

      Conserved Domains (1) summary
      pfam12576
      Location:1 → 123
      DUF3754; Protein of unknown function (DUF3754)

    4. XM_006541190.3 → XP_006541253.1  transmembrane protein 143 isoform X3

      Conserved Domains (1) summary
      pfam12576
      Location:1 → 123
      DUF3754; Protein of unknown function (DUF3754)

    5. XM_036153429.1 → XP_036009322.1  transmembrane protein 143 isoform X3

      Conserved Domains (1) summary
      pfam12576
      Location:1 → 123
      DUF3754; Protein of unknown function (DUF3754)

    RNA

    1. XR_003946562.2 RNA Sequence

      Related
      ENSMUST00000209292.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD26.1 GenPept UniProtKB/Swiss-Prot:Q8VD26

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