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    arfA peptidoglycan-binding protein ArfA [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885286, updated on 6-Oct-2023

    Summary

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    Gene symbol
    arfA
    Gene description
    peptidoglycan-binding protein ArfA
    Locus tag
    Rv0899
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    ompA; ompATb
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    Genomic context

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    Sequence:
    NC_000962.3 (1002812..1003792)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene oxidoreductase Neighboring gene hypothetical protein Neighboring gene membrane protein Neighboring gene membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural studies of Mycobacterium tuberculosis Rv0899 reveal a monomeric membrane-anchoring protein with two separate domains. Li J, et al. J Mol Biol, 2012 Jan 13. PMID 22108166
    2. Expression of OmpATb is dependent on small membrane proteins in Mycobacterium bovis BCG. Veyron-Churlet R, et al. Tuberculosis (Edinb), 2011 Nov. PMID 21802366
    3. Expression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environments. Song H, et al. Mol Microbiol, 2011 May. PMID 21410778, Free PMC Article
    4. Structure of the Mycobacterium tuberculosis OmpATb protein: a model of an oligomeric channel in the mycobacterial cell wall. Yang Y, et al. Proteins, 2011 Feb. PMID 21117233
    5. Mycobacterium tuberculosis Rv0899 adopts a mixed alpha/beta-structure and does not form a transmembrane beta-barrel. Teriete P, et al. Biochemistry, 2010 Apr 6. PMID 20199110, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data obtained from solution NMR and EPR spectroscopy indicated that Rv0899 is a monomeric membrane-anchoring protein with two separate domains, rather than an oligomeric pore.
      Title: Structural studies of Mycobacterium tuberculosis Rv0899 reveal a monomeric membrane-anchoring protein with two separate domains.
    2. Strains carrying a deletion of Rv0900 or frameshift mutation in either Rv0900 or Rv0901 results in strongly altered OmpATb expression, demonstrating that Rv0900 and Rv0901 play a regulatory role, which appears to occur at a post-transcriptional level.
      Title: Expression of OmpATb is dependent on small membrane proteins in Mycobacterium bovis BCG.
    3. OmpATb is not a general porin, but rather is involved in adaptation of M. tuberculosis to acidic environments by mediating ammonia secretion.
      Title: Expression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environments.
    4. the 3D structure of OmpATb by NMR in solution
      Title: Structure of the Mycobacterium tuberculosis OmpATb protein: a model of an oligomeric channel in the mycobacterial cell wall.
    5. characterized the structure and dynamics of the B and C domains and determined the three-dimensional structure of the B domain
      Title: Mycobacterium tuberculosis Rv0899 adopts a mixed alpha/beta-structure and does not form a transmembrane beta-barrel.
    6. The present study shows for the first time that the N terminus of OmpATb is required for targeting the porin to the cell wall and also appears to be essential for its pore-forming activity.
      Title: The N-terminal domain of OmpATb is required for membrane translocation and pore-forming activity in mycobacteria.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    peptidoglycan-binding protein ArfA
    NP_215414.1
    • outer membrane protein OmpA; Pore-forming activity is pH-dependent.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1002812..1003792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215414.1 peptidoglycan-binding protein ArfA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215414.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A221LCA5
      Conserved Domains (2) summary
      COG2885
      Location:174 → 326
      OmpA; Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis]
      pfam04972
      Location:145 → 196
      BON; BON domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WIU5.1

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