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    serA2 D-3-phosphoglycerate dehydrogenase SerA [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888555, updated on 6-Oct-2023

    Summary

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    Gene symbol
    serA2
    Gene description
    D-3-phosphoglycerate dehydrogenase SerA
    Locus tag
    Rv0728c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (820496..821476, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene L-fuculose phosphate aldolase FucA Neighboring gene D-xylulose kinase XylB Neighboring gene GCN5-like N-acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Mycobacterium tuberculosis SecA2 system subverts phagosome maturation to promote growth in macrophages. Sullivan JT, et al. Infect Immun, 2012 Mar. PMID 22215736, Free PMC Article
    2. D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes. Dey S, et al. J Biol Chem, 2005 Apr 15. PMID 15668250
    3. Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits. Dey S, et al. J Biol Chem, 2005 Apr 15. PMID 15668249
    4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibitors of phagosome acidification rescued the intracellular growth defect of the DeltasecA2 mutant, which demonstrated that the phagosome maturation arrest defect of the DeltasecA2 mutant is responsible for the intracellular growth defect.
      Title: The Mycobacterium tuberculosis SecA2 system subverts phagosome maturation to promote growth in macrophages.
    2. analysis of D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis
      Title: D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes.
    3. Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase has extreme asymmetry in a tetramer of identical subunits
      Title: Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    D-3-phosphoglycerate dehydrogenase SerA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      820496..821476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215242.1 D-3-phosphoglycerate dehydrogenase SerA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215242.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0E8IXF0
      Conserved Domains (1) summary
      cl21454
      Location:6 → 310
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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