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    Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Cricetulus griseus (Chinese hamster) ]

    Gene ID: 100689251, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Pik3ca
    Gene description
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
    Locus tag
    I79_017178
    See related
    Ensembl:ENSCGRG00015027160
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cricetulus griseus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
    Orthologs
    human mouse all
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    Genomic context

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    See Pik3ca in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614645.1 (205533..248231)
    104 current CriGri-PICRH-1.0 (GCF_003668045.3) 1 Unlocalized Scaffold NW_023276806.1 (116893443..116966254, complement)

    NW_003614645.1Genomic Context describing neighboring genes Neighboring gene zinc finger matrin-type 3 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3 Neighboring gene zinc finger protein 639

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IB IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Names
    phosphatidylinositol 3-kinase, catalytic, alpha polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CriGri_1.0 Primary Assembly

    Genomic

    1. NW_003614645.1 Reference CriGri_1.0 Primary Assembly

      Range
      205533..248231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007649683.4 → XP_007647873.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X2

      UniProtKB/TrEMBL
      A0A9J7H774
      Conserved Domains (5) summary
      cd08398
      Location:325 → 484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:173 → 292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain
      cl21453
      Location:695 → 832
      PKc_like; Protein Kinases, catalytic domain

    2. XM_003509075.5 → XP_003509123.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/TrEMBL
      A0A061IHE6, A0A8C2MP62
      Conserved Domains (5) summary
      cd08398
      Location:325 → 484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:31 → 108
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:173 → 292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:695 → 1064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

    3. XM_016979013.3 → XP_016834502.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/TrEMBL
      A0A061IHE6, A0A8C2MP62
      Conserved Domains (5) summary
      cd08398
      Location:325 → 484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:31 → 108
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:173 → 292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:695 → 1064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

    Alternate CriGri-PICRH-1.0

    Genomic

    1. NW_023276806.1 Alternate CriGri-PICRH-1.0

      Range
      116893443..116966254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027392022.1 → XP_027247823.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/TrEMBL
      A0A061IHE6, A0A8C2MP62

    2. XM_027392021.2 → XP_027247822.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/TrEMBL
      A0A061IHE6, A0A8C2MP62
      Related
      ENSCGRP00015040342.1, ENSCGRT00015058794.1

    3. XM_027392023.1 → XP_027247824.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/TrEMBL
      A0A061IHE6, A0A8C2MP62
      Related
      ENSCGRP00015036226.2, ENSCGRT00015044168.2

    4. XM_035450326.1 → XP_035306217.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X2

      UniProtKB/TrEMBL
      A0A9J7H774
      Conserved Domains (5) summary
      cd08398
      Location:325 → 484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:173 → 292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain
      cl21453
      Location:695 → 832
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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