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    TP53TG3B TP53 target 3B [ Homo sapiens (human) ]

    Gene ID: 729355, updated on 17-Jun-2024

    Summary

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    Official Symbol
    TP53TG3Bprovided by HGNC
    Official Full Name
    TP53 target 3Bprovided by HGNC
    Primary source
    HGNC:HGNC:37202
    See related
    Ensembl:ENSG00000261509 AllianceGenome:HGNC:37202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TP53TG3E; TP53TG3F
    Summary
    Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 7.8), placenta (RPKM 0.6) and 2 other tissues See more
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    Genomic context

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    See TP53TG3B in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (33360841..33363478)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (33608500..33611137)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (33262082..33264719)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene TP53 target 3 family member E Neighboring gene uncharacterized LOC105369266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:33238201-33238758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:33238759-33239314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:33239315-33239872 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr16:33239873-33240428 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr16:33240429-33240985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:33240986-33241541 Neighboring gene uncharacterized LOC105379473 Neighboring gene TP53 target 3 family member F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a novel TP53-inducible gene, TP53TG3. Ng CC, et al. Genes Chromosomes Cancer, 1999 Dec. PMID 10534768
    2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
    3. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • MGC119888

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TP53-target gene 3 protein
    Names
    TP53-inducible gene 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099687.4 → NP_001093157.1  TP53-target gene 3 protein

      See identical proteins and their annotated locations for NP_001093157.1

      Status: VALIDATED

      Source sequence(s)
      AC141257
      Consensus CDS
      CCDS45477.1
      UniProtKB/Swiss-Prot
      B2R5K6, Q4KN31, Q9ULY9, Q9ULZ0
      Related
      ENSP00000339405.5, ENST00000341305.7

    RNA

    1. NR_110897.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC141257

    2. NR_110911.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC141257

    3. NR_158181.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC141257

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      33360841..33363478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545933.2 → XP_011544235.1  TP53-target gene 3 protein isoform X1

      See identical proteins and their annotated locations for XP_011544235.1

      UniProtKB/Swiss-Prot
      Q9ULZ0
      Related
      ENSP00000457303.1, ENST00000567724.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      33608500..33611137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313823.1 → XP_054169798.1  TP53-target gene 3 protein isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001205265.1: Suppressed sequence

      Description
      NM_001205265.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULZ0.2 GenPept UniProtKB/Swiss-Prot:Q9ULZ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials