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    COQ3 coenzyme Q 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817642, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COQ3
    Official Full Name
    coenzyme Q 3
    Primary source
    TAIR:AT2G30920
    Locus tag
    AT2G30920
    See related
    Araport:AT2G30920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCOQ3; coenzyme Q 3; EMB3002; embryo defective 3002; F7F1.13; F7F1_13
    Summary
    The enzyme encoded by this gene has been shown to complement the Saccharomyces cerevisiae coq3 mutation and, therefore, to have hexaprenyldihydroxybenzoate methyltransferase activity. It is however likely that, in Arabidopsis, the enzyme catalyzes the methylation of nonaprenyldihydroxybenzoate as it is the prevalent polyprenoid in this plant species. The enzyme is a mitochondrial-localized methyltransferase involved in ubiquinone biosynthesis.
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    Genomic context

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    See COQ3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (13157089..13160886, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase PHI 10 Neighboring gene Pleckstrin homology (PH) domain-containing protein Neighboring gene Cytochrome b561/ferric reductase transmembrane protein family Neighboring gene TRICHOME BIREFRINGENCE-LIKE 43 Neighboring gene actin-related protein C1A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional expression of AtCOQ3, the Arabidopsis homologue of the yeast COQ3 gene, encoding a methyltransferase from plant mitochondria involved in ubiquinone biosynthesis. Avelange-Macherel MH, et al. Plant J, 1998 Apr. PMID 9628017
    2. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336307.1
    NM_128644.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables 3-demethylubiquinol-n 3-O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within methylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquinone biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    coenzyme Q 3
    NP_180649.1
    • coenzyme Q 3 (COQ3); CONTAINS InterPro DOMAIN/s: Methyltransferase type 11 (InterPro:IPR013216), Ubiquinone biosynthesis O-methyltransferase (InterPro:IPR010233); Has 7105 Blast hits to 7105 proteins in 1734 species: Archae - 120; Bacteria - 4165; Metazoa - 130; Fungi - 181; Plants - 86; Viruses - 0; Other Eukaryotes - 2423 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13157089..13160886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128644.4 → NP_180649.1  coenzyme Q 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49354, O80857, Q94AS6
      UniProtKB/TrEMBL
      A0A178VTB0, A0A5S9X330, A0A654EZ36, Q8LG57
      Conserved Domains (1) summary
      PLN02396
      Location:1 → 322
      PLN02396; hexaprenyldihydroxybenzoate methyltransferase

    2. NM_001336307.1 → NP_001324991.1  coenzyme Q 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49354, O80857, Q94AS6
      UniProtKB/TrEMBL
      A0A178VTB0, A0A5S9X330, A0A654EZ36, Q8LG57
      Conserved Domains (1) summary
      PLN02396
      Location:1 → 322
      PLN02396; hexaprenyldihydroxybenzoate methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49354.2

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