Adra1a adrenoceptor alpha 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adra1aprovided by RGD
Official Full Name: adrenoceptor alpha 1Aprovided by RGD
Primary source: RGD:2055
See related: EnsemblRapid:ENSRNOG00000009522 AllianceGenome:RGD:2055
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adra1c
Summary: Predicted to enable alpha1-adrenergic receptor activity and protein heterodimerization activity. Involved in several processes, including phospholipase C-activating adrenergic receptor signaling pathway; positive regulation of cell communication; and regulation of blood circulation. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and Z disc. Is active in several cellular components, including GABA-ergic synapse; dopaminergic synapse; and synaptic membrane. Used to study bladder neck obstruction. Biomarker of hypertension and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease; heroin dependence; and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 139.6), Kidney (RPKM 54.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (45005648..45111416)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (40830125..40935902)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (43296997..43398314)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Negative relationship between brain alpha1A-AR neurotransmission and betaArr2 levels in anxious adolescent rats subjected to early life stress.
Title: Negative relationship between brain α(1A)-AR neurotransmission and βArr2 levels in anxious adolescent rats subjected to early life stress.
Centruroides margaritatus scorpion complete venom exerts cardiovascular effects through alpha-1 adrenergic receptors.
Title: Centruroides margaritatus scorpion complete venom exerts cardiovascular effects through alpha-1 adrenergic receptors.
MAPKs Are Highly Abundant but Do Not Contribute to alpha1-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period.
Title: MAPKs Are Highly Abundant but Do Not Contribute to α(1)-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period.
Antidepressants Differentially Regulate Intracellular Signaling from alpha1-Adrenergic Receptor Subtypes In Vitro.
Title: Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.
those results suggested NE which stimulated alpha1A -adrenoceptor-mediated the proliferation of pulmonary artery smooth muscle cells (PASMCs), which may be via the CaMKII pathway, and it could be used as a novel treatment strategy in Pulmonary arterial hypertension (PAH).
Title: alpha1A-adrenoceptor is involved in norepinephrine-induced proliferation of pulmonary artery smooth muscle cells via CaMKII signaling.
the importance of alpha1A-AR in the peripheral control of ejaculatio
Title: Contraction of Rat Cauda Epididymis Smooth Muscle to α(1)-Adrenoceptor Activation Is Mediated by α(1A)-Adrenoceptors.
Heterologous expression of the alpha1-adrenergic receptors in HEK 293 cell showed accumulation of cAMP in response to phenylephrine in the nucleus and cytoplasm in a GTP-binding proteins-dependent manner.
Title: Receptor- and cellular compartment-specific activation of the cAMP/PKA pathway by α(1)-adrenergic and ETA endothelin receptors.
Study demonstrates that MRI allows a precocious detection of the subtle myocardial dysfunction induced by beta1-adrenoreceptors-autoantibodies (beta1-aabs) and that beta3-adrenoreceptor stimulation blunts the development of beta1-aabs-induced dilated cardiomyopathy.
Title: MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression.
Chronic stress (water avoidance stress) animals present high levels of urinary noradrenaline, and we find the bladder dysfunctions in these animals are mediated by alpha 1A adrenoceptors, as Silodosin administration prevents the appearance of these alterations.
Title: The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation.
the excitatory input and post-synaptic dynamics of pontine reticular nucleus reticulospinal neurons are indeed intricately modulated by the activation of alpha1- and alpha2-adrenoceptors.
Title: Adrenoceptor-Mediated Post- and Pre-Synaptic Regulations of the Reticulospinal Neurons in Rat Caudal Pontine Reticular Nucleus.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC150908P4 (e-PCR)
- UniSTS:271119

D15Got50 (e-PCR)
- UniSTS:113737

PMC123165P1 (e-PCR)
- UniSTS:270443

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha1-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha1-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adult heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult heart development	ISO Inferred from Sequence Orthology more info
involved_in cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in neuron-glial cell signaling	IEA Inferred from Electronic Annotation more info
involved_in neuron-glial cell signaling	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ growth	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating adrenergic receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pilomotor reflex	IEA Inferred from Electronic Annotation more info
involved_in pilomotor reflex	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart rate by epinephrine-norepinephrine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of heart rate by epinephrine-norepinephrine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase C signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of the force of heart contraction by epinephrine-norepinephrine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dopaminergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-1A adrenergic receptor

Names: adrenergic alpha 1c receptor; adrenergic receptor alpha 1c subtype; adrenergic receptor, alpha 1a; adrenergic receptor, alpha 1c; adrenergic, alpha-1A-, receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017191.2 → NP_058887.2 alpha-1A adrenergic receptor

See identical proteins and their annotated locations for NP_058887.2

Status: PROVISIONAL

Source sequence(s)

U07126

UniProtKB/Swiss-Prot

P43140

UniProtKB/TrEMBL

A6K6N1

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

45005648..45111416

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252109.5 → XP_006252171.1 alpha-1A adrenergic receptor isoform X3

UniProtKB/TrEMBL

A0A8L2Q6V0

Related

ENSRNOP00000012736.2, ENSRNOT00000012736.5

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor
XM_063274182.1 → XP_063130252.1 alpha-1A adrenergic receptor isoform X2

Related

ENSRNOP00000103621.1, ENSRNOT00000163065.1
XM_006252107.5 → XP_006252169.1 alpha-1A adrenergic receptor isoform X1

See identical proteins and their annotated locations for XP_006252169.1

UniProtKB/Swiss-Prot

P43140

UniProtKB/TrEMBL

A6K6N1

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039093213.2 → XP_038949141.1 alpha-1A adrenergic receptor isoform X4

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063274181.1 → XP_063130251.1 alpha-1A adrenergic receptor isoform X1

UniProtKB/Swiss-Prot

P43140

UniProtKB/TrEMBL

A6K6N1
XM_006252110.5 → XP_006252172.1 alpha-1A adrenergic receptor isoform X5

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor