h1-0.L H1.0 linker histone L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: h1-0.L
Official Full Name: H1.0 linker histone L homeolog
Primary source: Xenbase:XB-GENE-865333
Locus tag: XELAEV_18023705mg
See related: EnsemblRapid:ENSXLAG00005026381 AllianceGenome:Xenbase:XB-GENE-865333
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: h10; h1f0; h1fv; H1zero; h1-0-a; h1f0-a; h1f0-b; h1f0.L; h1(0)-1
Summary: Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be a structural constituent of chromatin. Predicted to act upstream of or within chromosome condensation; negative regulation of DNA recombination; and nucleosome assembly. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. Orthologous to human H1-0 (H1.0 linker histone). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (120712096..120714290, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (115392261..115394455, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization.
Title: Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization.
Data suggest that Nap1 readily dissociates histone 1 (H1) from DNA and stoichiometrically binds H1 from nucleosomes, supporting a hypothesis whereby histone chaperones contribute to regulation of H1 profile in chromatin.
Title: Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome.
Thus, our results indicate that linker histone H1 plays an important role in the structure and function of vertebrate chromosomes in mitosis.
Title: Histone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables nucleosomal DNA binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosome condensation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone H1.0-A

Names: H1 histone family member 0 L homeolog; H1 histone family, member 0; H1-SB; H1E; histone H1(0)-1; histone H5B; xlH5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089228.1 → NP_001082697.1 histone H1.0-A

See identical proteins and their annotated locations for NP_001082697.1

Status: PROVISIONAL

Source sequence(s)

BC072941

UniProtKB/Swiss-Prot

P22845, Q7SZ41, Q91759

UniProtKB/TrEMBL

A0A974D761

Related

ENSXLAP00005078380.1, ENSXLAT00005079971.1

Conserved Domains (1) summary

pfam00538
Location:23 → 94

Linker_histone; linker histone H1 and H5 family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

120712096..120714290 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)