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    Ftcd formiminotransferase cyclodeaminase [ Mus musculus (house mouse) ]

    Gene ID: 14317, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ftcdprovided by MGI
    Official Full Name
    formiminotransferase cyclodeaminaseprovided by MGI
    Primary source
    MGI:MGI:1339962
    See related
    Ensembl:ENSMUSG00000001155 AllianceGenome:MGI:1339962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; and microtubule binding activity. Predicted to be involved in cytoskeleton organization. Predicted to act upstream of or within L-histidine catabolic process. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in liver adult (RPKM 178.1), liver E18 (RPKM 58.0) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ftcd in Genome Data Viewer
    Location:
    10 C1; 10 39.25 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76411482..76426172)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76575648..76590338)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930483K19 gene Neighboring gene lanosterol synthase Neighboring gene spermatogenesis and centriole associated 1 like Neighboring gene predicted gene 15343 Neighboring gene collagen, type VI, alpha 2 Neighboring gene predicted gene, 51774

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma. Liu Y, et al. Biomolecules, 2023 Dec 28. PMID 38254641, Free PMC Article
    2. Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency. Solans A, et al. Cytogenet Cell Genet, 2000. PMID 10773664
    3. Forkhead box p3+ regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis. Lapierre P, et al. Hepatology, 2010 May. PMID 20232291
    4. Cloning of mouse ojoplano, a reticular cytoplasmic protein expressed during embryonic development. Mertes F, et al. Gene Expr Patterns, 2009 Dec. PMID 19766735
    5. ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. Zahn C, et al. J Biol Chem, 2008 Oct 3. PMID 18662990

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
      Title: Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
    2. Autoreactive B cell response against formiminotransferase-cyclodeaminase correlated with disease activity, possibly linking B-cell autoreactivity and AIH pathogenesis
      Title: Forkhead box p3+ regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (9) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables folic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formimidoyltetrahydrofolate cyclodeaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables formimidoyltetrahydrofolate cyclodeaminase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables glutamate formimidoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamate formimidoyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-histidine catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in L-histidine catabolic process to glutamate and formamide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine catabolic process to glutamate and formate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in smooth endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in smooth endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    formimidoyltransferase-cyclodeaminase
    Names
    glutamate formiminotransferase
    NP_543121.1
    XP_006513278.1
    XP_006513279.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080845.2 → NP_543121.1  formimidoyltransferase-cyclodeaminase

      See identical proteins and their annotated locations for NP_543121.1

      Status: VALIDATED

      Source sequence(s)
      AK165414, BB610765, CB949427, CD297973
      Consensus CDS
      CCDS23950.1
      UniProtKB/Swiss-Prot
      Q91XD4
      Related
      ENSMUSP00000001183.8, ENSMUST00000001183.8
      Conserved Domains (2) summary
      TIGR02024
      Location:1 → 328
      FtcD; glutamate formiminotransferase
      pfam04961
      Location:340 → 519
      FTCD_C; Formiminotransferase-cyclodeaminase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      76411482..76426172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513216.3 → XP_006513279.1  formimidoyltransferase-cyclodeaminase isoform X2

      Conserved Domains (3) summary
      pfam02971
      Location:32 → 175
      FTCD; Formiminotransferase domain
      pfam04961
      Location:190 → 363
      FTCD_C; Formiminotransferase-cyclodeaminase
      cl26845
      Location:4 → 30
      FTCD_N; Formiminotransferase domain, N-terminal subdomain

    2. XM_006513215.3 → XP_006513278.1  formimidoyltransferase-cyclodeaminase isoform X1

      Conserved Domains (2) summary
      pfam04961
      Location:323 → 496
      FTCD_C; Formiminotransferase-cyclodeaminase
      cl26845
      Location:2 → 312
      FTCD_N; Formiminotransferase domain, N-terminal subdomain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XD4.1 GenPept UniProtKB/Swiss-Prot:Q91XD4

    Gene LinkOut

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