Pdia5 protein disulfide isomerase associated 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdia5provided by MGI
Official Full Name: protein disulfide isomerase associated 5provided by MGI
Primary source: MGI:MGI:1919849
See related: Ensembl:ENSMUSG00000022844 AllianceGenome:MGI:1919849
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pdir; 2700053F16Rik
Summary: Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in retina and skeleton. Orthologous to human PDIA5 (protein disulfide isomerase family A member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in placenta adult (RPKM 48.4), liver E18 (RPKM 23.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 25.37 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (35217678..35311289, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (35397308..35490919, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy.
Title: Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy.
protein disulfide isomerase 5 is deregulated in the mucopolysaccharidoses, although the unfolded protein response is not activated
Title: Unfolded protein response is not activated in the mucopolysaccharidoses but protein disulfide isomerase 5 is deregulated.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein disulfide isomerase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein disulfide-isomerase A5

Names: protein disulfide isomerase-related protein

NP_082571.1

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028295.1 → NP_082571.1 protein disulfide-isomerase A5 precursor

See identical proteins and their annotated locations for NP_082571.1

Status: PROVISIONAL

Source sequence(s)

BC009151

Consensus CDS

CCDS37323.1

UniProtKB/Swiss-Prot

Q921X9

Related

ENSMUSP00000023550.8, ENSMUST00000023550.9

Conserved Domains (3) summary

cd02997
Location:396 → 499

PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...

cd03067
Location:26 → 137

PDI_b_PDIR_N; PDIb family, PDIR subfamily, N-terminal TRX-like b domain; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. ...

PTZ00102
Location:122 → 517

PTZ00102; disulphide isomerase; Provisional