REG4 regenerating family member 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: REG4provided by HGNC
Official Full Name: regenerating family member 4provided by HGNC
Primary source: HGNC:HGNC:22977
See related: Ensembl:ENSG00000134193 MIM:609846; AllianceGenome:HGNC:22977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GISP; RELP; REG-IV
Summary: Enables heparin binding activity and mannan binding activity. Predicted to act upstream of or within response to bacterium. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in small intestine (RPKM 174.4), colon (RPKM 137.8) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (119794017..119811460, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (119807250..119824685, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (120336640..120354083, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly.
Title: Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly.
The effects of REG4 expression on chemoresistance of ovarian cancer.
Title: The effects of REG4 expression on chemoresistance of ovarian cancer.
Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24.
Title: Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24.
Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells.
Title: Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells.
Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer.
Title: Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer.
CDX2 and Reg IV expression and correlation in gastric cancer.
Title: CDX2 and Reg IV expression and correlation in gastric cancer.
A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/beta-catenin signaling.
Title: A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling.
The correlation of CDX2 with Reg IV expression was demonstrated in ovarian mucinous carcinoma. Reg IV expression was enhanced by transfection of CDX2 and was suppressed by inhibition of CDX2 expression. OMC-3 cells with ectopically overexpressed CDX2 showed enhanced apoptosis and sensitivity to 5-FU.
Title: Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma.
REG4 plays an important role in KRAS-driven lung cancer pathogenesis and is a novel biomarker of lung adenocarcinoma subtype. Future studies are required to clarify the underlying mechanisms of REG4 in the division and proliferation of KC tumors and its potential therapeutic value.
Title: REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression.
Our study demonstrated that Reg IV positively regulates the expression of SOX9 and is involved in tumor cell invasion and migration in gastric cancer.
Title: Expression of Reg IV and SOX9 and their correlation in human gastric cancer.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-149761 (e-PCR)
- UniSTS:177202

AL033808 (e-PCR)
- UniSTS:93673

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables mannan binding	IBA Inferred from Biological aspect of Ancestor more info
enables mannan binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regenerating islet-derived protein 4

Names: REG-4; REG-like protein; gastrointestinal secretory protein; reg IV; regenerating gene type IV; regenerating islet-derived family, member 4; regenerating islet-derived protein IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159352.2 → NP_001152824.1 regenerating islet-derived protein 4 isoform 1 precursor

See identical proteins and their annotated locations for NP_001152824.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AL359752, AY126670

Consensus CDS

CCDS906.1

UniProtKB/Swiss-Prot

Q8NER6, Q8NER7, Q9BYZ8

Related

ENSP00000346158.1, ENST00000354219.5

Conserved Domains (1) summary

cd03594
Location:30 → 156

CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
NM_001159353.2 → NP_001152825.1 regenerating islet-derived protein 4 isoform 2 precursor

See identical proteins and their annotated locations for NP_001152825.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks several 3' exons but has an alternate 3' end, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.

Source sequence(s)

AL359752, AY126672

Consensus CDS

CCDS53354.1

UniProtKB/Swiss-Prot

Q9BYZ8

Related

ENSP00000358409.4, ENST00000369401.4

Conserved Domains (1) summary

cl02432
Location:30 → 55

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
NM_032044.4 → NP_114433.1 regenerating islet-derived protein 4 isoform 1 precursor

See identical proteins and their annotated locations for NP_114433.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

AL359752, AY007243, AY126670

Consensus CDS

CCDS906.1

UniProtKB/Swiss-Prot

Q8NER6, Q8NER7, Q9BYZ8

Related

ENSP00000256585.5, ENST00000256585.10

Conserved Domains (1) summary

cd03594
Location:30 → 156

CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)