Slc22a2 solute carrier family 22 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a2provided by RGD
Official Full Name: solute carrier family 22 member 2provided by RGD
Primary source: RGD:61936
See related: EnsemblRapid:ENSRNOG00000016625 AllianceGenome:RGD:61936
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OCT2; OCT2r; rOCT2
Summary: Enables several functions, including monoamine transmembrane transporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including acetylcholine transport; histamine transport; and monoamine transport. Acts upstream of or within positive regulation of gene expression. Located in apical plasma membrane and basolateral plasma membrane. Is active in cholinergic synapse; presynaptic membrane; and synaptic vesicle membrane. Used to study acute kidney failure. Biomarker of cholestasis (multiple); hyperuricemia; and kidney failure (multiple). Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 601.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (50668817..50711019, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (48121061..48163268, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (48318025..48360219, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.
Title: Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.
Although multiple factors may influence renal handling of drugs, these observations can be accounted for, at least in part, by downregulation of Mate1-mediated apical efflux from tubular cells and Oct2-mediated basolateral uptake. Our results suggest that hyperuricemia could alter the disposition of drugs that are substrates of Mate1 and/or Oct2.
Title: Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
findings indicate that OCT2 knockout possibly mitigate OTA-induced apoptosis by preventing the increase of Caspase 3 and CDK1
Title: Mitigation of cell apoptosis induced by ochratoxin A (OTA) is possibly through organic cation transport 2 (OCT2) knockout.
These results provide the first identification of a high affinity neuronal transporter for p-tyramine, and also confirm the recently described localization of OCT2 in pre-synaptic terminals.
Title: Pharmacological characterization of a high-affinity p-tyramine transporter in rat brain synaptosomes.
Formononetin prevents cisplatin-induced acute kidney injury by targeting Oct2/TP53 in the kidney.
Title: Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury.
Renal rOCT2 levels, but not rOCT1 and rMATE1, were significantly lowered in female rats.
Title: Gender-Related Differences in the Expression of Organic Cation Transporter 2 and its Role in Urinary Excretion of Metformin in Rats.
A significant age-related decrease in rOCT2 protein expression was observed.
Title: Role of age-related decrease of renal organic cation transporter 2 in the effect of atenolol on renal excretion of metformin in rats.
cisplatin uptake was increased by OCT2 overexpression in male, but not female rats and associated with increased cellular sensitivity to cisplatin toxicity
Title: Sex and age differences related to renal OCT2 gene expression in cisplatin-induced nephrotoxicity.
Data show that lycopene upregulated the organic anion transporters (OAT1 and OAT3) and organic cation transporters (OCT1 and OCT2) in cisplatin-induced acute renal injury.
Title: Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation.
liver I/R decreases the tubular secretion of cimetidine, mainly because of the decreased rOCT2 level in the kidney, and that oxidative stress should be responsible in part for decreased renal rOCT2 after liver I/R injury.
Title: Altered pharmacokinetics of cimetidine caused by down-regulation of renal rat organic cation transporter 2 (rOCT2) after liver ischemia-reperfusion injury.

Submit: New GeneRIF Correction See all GeneRIFs (29)

General gene information

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Markers

Slc22a2 (e-PCR), detects polymorphism
- UniSTS:463369

Slc22a2 (e-PCR), detects polymorphism
- UniSTS:144419

D5Bwg0676e (e-PCR), detects polymorphism
- UniSTS:142536

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables acetylcholine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables amine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables choline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables choline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables putrescine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables putrescine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables putrescine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyrimidine nucleoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables pyrimidine nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables quaternary ammonium group transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables quaternary ammonium group transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables quaternary ammonium group transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables spermidine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables thiamine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables thiamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thiamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables toxin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables toxin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables toxin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in acetylcholine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in acetylcholine transport	IEA Inferred from Electronic Annotation more info
involved_in acetylcholine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amine transport	IEA Inferred from Electronic Annotation more info
involved_in amine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in choline transport	IEA Inferred from Electronic Annotation more info
involved_in choline transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake	IEA Inferred from Electronic Annotation more info
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in epinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in epinephrine transport	IEA Inferred from Electronic Annotation more info
involved_in epinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in histamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in histamine transport	ISO Inferred from Sequence Orthology more info
involved_in histamine uptake	IEA Inferred from Electronic Annotation more info
involved_in histamine uptake	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in norepinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine uptake	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in organic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic cation transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within organic cation transport	ISO Inferred from Sequence Orthology more info
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin transport	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in putrescine transport	IEA Inferred from Electronic Annotation more info
involved_in putrescine transport	ISO Inferred from Sequence Orthology more info
involved_in putrescine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in quaternary ammonium group transport	IDA Inferred from Direct Assay more info	PubMed
involved_in quaternary ammonium group transport	IEA Inferred from Electronic Annotation more info
involved_in serotonin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in serotonin uptake	IEA Inferred from Electronic Annotation more info
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in spermidine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in spermidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in thiamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in thiamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thiamine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cholinergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 22 member 2

Names: organic cation transporter 2; solute carrier family 22 (organic cation transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031584.2 → NP_113772.1 solute carrier family 22 member 2

See identical proteins and their annotated locations for NP_113772.1

Status: PROVISIONAL

Source sequence(s)

D83044

UniProtKB/Swiss-Prot

P70485, P97558, Q9R0W2

UniProtKB/TrEMBL

A0A0G2JSP9, A6KJX5

Related

ENSRNOP00000023116.2, ENSRNOT00000023116.7

Conserved Domains (2) summary

cd06174
Location:125 → 492

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:12 → 525

2A0119; cation transport protein