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    ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 [ Bos taurus (domestic cattle) ]

    Gene ID: 513140, updated on 4-Oct-2024

    Summary

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    Official Symbol
    ADAMTS10provided by VGNC
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 10provided by VGNC
    Primary source
    VGNC:VGNC:25615
    See related
    BGD:BT15564; Ensembl:ENSBTAG00000014207
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ADAMTS10 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (17159711..17183034, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene myosin IF Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC112447352 Neighboring gene microRNA mir-339b Neighboring gene NFIL3 like basic leucine zipper Neighboring gene actin like 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205750.1 → NP_001192679.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor

      See identical proteins and their annotated locations for NP_001192679.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000007
      UniProtKB/TrEMBL
      E1BMV7
      Conserved Domains (6) summary
      smart00209
      Location:550 → 602
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:239 → 454
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:239 → 457
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:64 → 179
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:706 → 818
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1069 → 1101
      PLAC; PLAC (protease and lacunin) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      17159711..17183034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010806923.4 → XP_010805225.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X5

      See identical proteins and their annotated locations for XP_010805225.1

      UniProtKB/TrEMBL
      E1BMV7
      Related
      ENSBTAP00000018887.4, ENSBTAT00000018887.6
      Conserved Domains (6) summary
      smart00209
      Location:550 → 602
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:239 → 454
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:239 → 457
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:64 → 179
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:706 → 818
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1069 → 1101
      PLAC; PLAC (protease and lacunin) domain

    2. XM_059888119.1 → XP_059744102.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X3

    3. XM_059888117.1 → XP_059744100.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

    4. XM_059888118.1 → XP_059744101.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X2

    5. XM_059888120.1 → XP_059744103.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X4

    6. XM_024994160.2 → XP_024849928.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

      Conserved Domains (5) summary
      smart00209
      Location:573 → 625
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:239 → 454
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:40 → 180
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:729 → 841
      ADAM_spacer1; ADAM-TS Spacer 1
      cl25800
      Location:890 → 1070
      GGN; Gametogenetin
    Nucleotide Protein Strain
    Heading Accession and Version

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