U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    SPDYE5 speedy/RINGO cell cycle regulator family member E5 [ Homo sapiens (human) ]

    Gene ID: 442590, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SPDYE5provided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member E5provided by HGNC
    Primary source
    HGNC:HGNC:35464
    See related
    Ensembl:ENSG00000170092 AllianceGenome:HGNC:35464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in testis (RPKM 3.6), skin (RPKM 1.2) and 23 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SPDYE5 in Genome Data Viewer
    Location:
    7q11.23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (75491630..75504316)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (76779599..76791648)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (75121598..75133640)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901676 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75039418-75040358 Neighboring gene NSUN5 pseudogene 1 Neighboring gene POM121 transmembrane nucleoporin C Neighboring gene 7q11.23 proximal recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18294 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75083199-75083700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18295 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75115301-75115800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18297 Neighboring gene Sharpr-MPRA regulatory region 5953 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75160518-75161214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26178 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 3 Neighboring gene huntingtin interacting protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75224249-75225196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75232242-75233192 Neighboring gene MPRA-validated peak6604 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75240777-75241350 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75246639-75247140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75252505-75253458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75253459-75254412 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75260462-75260962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18298 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75268875-75269629 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75269630-75270383 Neighboring gene Sharpr-MPRA regulatory region 13243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:75359065-75359566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18299

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    speedy protein E5
    Names
    putative Speedy protein E5
    speedy homolog E5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306141.4 → NP_001293070.1  speedy protein E5

      Status: VALIDATED

      Source sequence(s)
      AC211429
      Consensus CDS
      CCDS78241.1
      UniProtKB/Swiss-Prot
      A0A096LPK5, A6NIY4
      Related
      ENSP00000485398.1, ENST00000625065.4
      Conserved Domains (2) summary
      pfam12406
      Location:13 → 90
      DUF3664; Surface protein
      pfam11357
      Location:194 → 398
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      75491630..75504316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420408.1 → XP_047276364.1  speedy protein E5 isoform X2

      UniProtKB/Swiss-Prot
      A0A096LPK5, A6NIY4

    2. XM_047420407.1 → XP_047276363.1  speedy protein E5 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      76779599..76791648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001099435.2: Suppressed sequence

      Description
      NM_001099435.2: This RefSeq was suppressed because currently there is insufficient support for the transcript and the protein, and the transcript may retain intronic sequence at its 5' end.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NIY4.3 GenPept UniProtKB/Swiss-Prot:A6NIY4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials