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    MEIS3 Meis homeobox 3 [ Homo sapiens (human) ]

    Gene ID: 56917, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MEIS3provided by HGNC
    Official Full Name
    Meis homeobox 3provided by HGNC
    Primary source
    HGNC:HGNC:29537
    See related
    Ensembl:ENSG00000105419 MIM:619443; AllianceGenome:HGNC:29537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRG2
    Summary
    This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]
    Expression
    Biased expression in endometrium (RPKM 15.5), brain (RPKM 9.1) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MEIS3 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47403124..47422233, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50228571..50253087, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47906381..47925490, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47852412-47853316 Neighboring gene complement C5a receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47858319-47858818 Neighboring gene DExH-box helicase 34 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47895565-47896211 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47896212-47896859 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47901415-47902082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905147-47905846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905847-47906546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47906547-47907244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47920878-47921870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47921871-47922864 Neighboring gene hESC enhancers GRCh37_chr19:47931091-47931659 and GRCh37_chr19:47931660-47932227 Neighboring gene Sharpr-MPRA regulatory region 169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47939851-47940352 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47945299-47945446 Neighboring gene solute carrier family 8 member A2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47949904-47950829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47971701-47972200 Neighboring gene Sharpr-MPRA regulatory region 3844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14866 Neighboring gene NAPA antisense RNA 1 Neighboring gene kaptin, actin binding protein Neighboring gene NSF attachment protein alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt. Cai P, et al. Biomed Res Int, 2020. PMID 33376716, Free PMC Article
    2. MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect. Toyotome T, et al. J Toxicol Sci, 2016 Feb. PMID 26763390
    3. An autoinhibitory effect of the homothorax domain of Meis2. Hyman-Walsh C, et al. FEBS J, 2010 Jun. PMID 20553494, Free PMC Article
    4. Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development. Uribe RA, et al. Mol Biol Cell, 2015 Nov 1. PMID 26354419, Free PMC Article
    5. Identification of a new family of Pbx-related homeobox genes. Nakamura T, et al. Oncogene, 1996 Nov 21. PMID 8950991

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt.
      Title: Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt.
    2. Findings support a model in which Meis3 is required for neural crest proliferation, migration into, and colonization of the gut such that its loss leads to severe defects in enteric nervous system development.
      Title: Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development.
    3. This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect.
      Title: An autoinhibitory effect of the homothorax domain of Meis2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp547H236

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Meis3
    Names
    Meis1, myeloid ecotropic viral integration site 1 homolog 3
    meis1-related protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051644.1 RefSeqGene

      Range
      7707..24110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001009813.3 → NP_001009813.1  homeobox protein Meis3 isoform 2

      See identical proteins and their annotated locations for NP_001009813.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses alternate in-frame acceptor splice sites at two internal exon junctions compared to variant 1, which results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.
      Source sequence(s)
      AL537583, BC069251, CF993984
      Consensus CDS
      CCDS46132.1
      UniProtKB/Swiss-Prot
      A8K0S8
      Related
      ENSP00000388667.2, ENST00000441740.6
      Conserved Domains (2) summary
      pfam05920
      Location:263 → 302
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 162
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. NM_001301059.2 → NP_001287988.1  homeobox protein Meis3 isoform 3

      See identical proteins and their annotated locations for NP_001287988.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AL537583, BC045741, BI522513, BM783223, CF993984
      Consensus CDS
      CCDS74406.1
      UniProtKB/Swiss-Prot
      A8K0S8, A8K1N5, Q6NT73, Q8TC66, Q99687, Q9NPW2
      Related
      ENSP00000454073.1, ENST00000558555.6
      Conserved Domains (2) summary
      pfam05920
      Location:280 → 319
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 179
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. NM_001346148.2 → NP_001333077.1  homeobox protein Meis3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC073548
      UniProtKB/Swiss-Prot
      A8K0S8

    4. NM_020160.3 → NP_064545.1  homeobox protein Meis3 isoform 1

      See identical proteins and their annotated locations for NP_064545.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL537583, BC025404, CF993984, DB545063
      Consensus CDS
      CCDS33064.1
      UniProtKB/Swiss-Prot
      A8K0S8
      Related
      ENSP00000453307.1, ENST00000561293.5
      Conserved Domains (2) summary
      pfam05920
      Location:329 → 365
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 179
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      47403124..47422233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451615.2 → XP_024307383.1  homeobox protein Meis3 isoform X4

      UniProtKB/Swiss-Prot
      A8K0S8
      Conserved Domains (2) summary
      pfam05920
      Location:326 → 362
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:93 → 176
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. XM_024451616.2 → XP_024307384.1  homeobox protein Meis3 isoform X6

      UniProtKB/Swiss-Prot
      A8K0S8
      UniProtKB/TrEMBL
      H3BLU4
      Related
      ENSP00000333552.4, ENST00000331559.9
      Conserved Domains (2) summary
      pfam05920
      Location:312 → 348
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 162
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. XM_024451617.2 → XP_024307385.1  homeobox protein Meis3 isoform X7

      Related
      ENST00000561204.5
      Conserved Domains (2) summary
      pfam05920
      Location:197 → 233
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:1 → 47
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. XM_017027011.2 → XP_016882500.1  homeobox protein Meis3 isoform X5

      UniProtKB/TrEMBL
      H0YNA8
      Related
      ENSP00000453934.1, ENST00000561096.5

    5. XM_024451613.2 → XP_024307381.1  homeobox protein Meis3 isoform X2

      Conserved Domains (2) summary
      pfam05920
      Location:400 → 436
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:184 → 250
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    6. XM_024451612.2 → XP_024307380.1  homeobox protein Meis3 isoform X1

      Conserved Domains (2) summary
      pfam05920
      Location:417 → 453
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:184 → 267
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    7. XM_011527136.4 → XP_011525438.1  homeobox protein Meis3 isoform X3

      Conserved Domains (2) summary
      pfam05920
      Location:351 → 390
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:184 → 250
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    8. XM_047439109.1 → XP_047295065.1  homeobox protein Meis3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      50228571..50253087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321499.1 → XP_054177474.1  homeobox protein Meis3 isoform X4

    2. XM_054321501.1 → XP_054177476.1  homeobox protein Meis3 isoform X6

      UniProtKB/TrEMBL
      H3BLU4

    3. XM_054321502.1 → XP_054177477.1  homeobox protein Meis3 isoform X7

    4. XM_054321500.1 → XP_054177475.1  homeobox protein Meis3 isoform X5

      UniProtKB/TrEMBL
      H0YNA8

    5. XM_054321497.1 → XP_054177472.1  homeobox protein Meis3 isoform X2

    6. XM_054321495.1 → XP_054177470.1  homeobox protein Meis3 isoform X1

    7. XM_054321498.1 → XP_054177473.1  homeobox protein Meis3 isoform X3

    8. XM_054321496.1 → XP_054177471.1  homeobox protein Meis3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99687.3 GenPept UniProtKB/Swiss-Prot:Q99687

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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