FGF4 fibroblast growth factor 4 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: FGF4
Gene description: fibroblast growth factor 4
See related: Ensembl:ENSBTAG00000012563
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: HST; HBGF-4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	29	NC_037356.1 (47001981..47003919, complement)

Chromosome 29 - NC_037356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HisbFGF4, a 6x histidine-tagged bovine FGF4 (Pro(32) -Leu(206) ), was produced in Escherichia coli based on the validated nucleotide sequence and purified by heparin column chromatography.
Title: Production of bioactive bovine fibroblast growth factor 4 in E. coli based on the common nucleotide sequence of its structural gene in three breeds.
Present study provides a simple method for the production of a bioactive bovine FGF4 derivative in E.coli utilizing its structural gene.
Title: Production of bioactive bovine fibroblast growth factor 4 in E. coli based on the common nucleotide sequence of its structural gene in three breeds.
This is the first determination of the complete nucleotide sequence of the structural gene encoding bovine FGF4 in identified breeds.
Title: Common nucleotide sequence of structural gene encoding fibroblast growth factor 4 in eight cattle derived from three breeds.
this is the first determination of the complete nucleotide sequence of the structural gene encoding bovine FGF4 in identified breeds
Title: Common nucleotide sequence of structural gene encoding fibroblast growth factor 4 in eight cattle derived from three breeds.
Fgf4 exhibited significant hypermethylation in sperm compared with that in oocytes
Title: Methylation patterns in 5' terminal regions of pluripotency-related genes in mature bovine gametes.

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General gene information

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Markers

Fgf4 (e-PCR), detects polymorphism
- UniSTS:158730

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 4

Names: fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene); heparin secretory-transforming protein; heparin-binding growth factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.