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    CAPN2 calpain 2 [ Felis catus (domestic cat) ]

    Gene ID: 101083231, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CAPN2
    Official Full Name
    calpain 2
    Primary source
    VGNC:VGNC:60354
    See related
    EnsemblRapid:ENSFCTG00005005501
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    See CAPN2 in Genome Data Viewer
    Location:
    chromosome: F1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) F1 NC_058384.1 (606602..644935)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) F1 NC_018739.3 (2621254..2659938)

    Chromosome F1 - NC_058384.1Genomic Context describing neighboring genes Neighboring gene calpain-8 Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene tumor protein p53 binding protein 2 Neighboring gene uncharacterized LOC123382885 Neighboring gene uncharacterized LOC123382848

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain-2 catalytic subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058384.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      606602..644935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045049152.1 → XP_044905087.1  calpain-2 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A5F5XGT7, A0A5F5XU20
      Related
      ENSFCTP00005010459.1, ENSFCTT00005015437.1
      Conserved Domains (4) summary
      smart00230
      Location:32 → 352
      CysPc; Calpain-like thiol protease family
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd15897
      Location:533 → 561
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:533 → 693
      EFh_PEF; The penta-EF hand (PEF) family

    2. XM_023247642.2 → XP_023103410.1  calpain-2 catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0A5F5XGT7, M3WDP6
      Related
      ENSFCTP00005010483.1, ENSFCTT00005015465.1
      Conserved Domains (3) summary
      cd00214
      Location:354 → 510
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16199
      Location:533 → 700
      EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version

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