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    Neu3 neuraminidase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Neu3provided by RGD
    Official Full Name
    neuraminidase 3provided by RGD
    Primary source
    RGD:619881
    See related
    EnsemblRapid:ENSRNOG00000018106 AllianceGenome:RGD:619881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable exo-alpha-sialidase activity. Predicted to be involved in several processes, including ganglioside catabolic process; negative regulation of clathrin-dependent endocytosis; and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in bounding membrane of organelle and external side of plasma membrane. Predicted to be active in lysosome and membrane. Orthologous to human NEU3 (neuraminidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 22.0), Muscle (RPKM 13.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Neu3 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (163549834..163560997, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154137732..154148879, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (164803574..164814777, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 36 Neighboring gene olfactory receptor family 2 subfamily AT member 1 Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene uncharacterized LOC134483763 Neighboring gene signal peptidase complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons. Kappagantula S, et al. J Neurosci, 2014 Feb 12. PMID 24523539, Free PMC Article
    2. NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids. Lipina C, et al. Cell Signal, 2015 Sep. PMID 26022181
    3. Differential expression of three sialidase genes in rat development. Hasegawa T, et al. Biochem Biophys Res Commun, 2001 Jan 26. PMID 11162581
    4. Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice. Sasaki A, et al. J Biol Chem, 2003 Jul 25. PMID 12730204
    5. Asymmetric membrane ganglioside sialidase activity specifies axonal fate. Da Silva JS, et al. Nat Neurosci, 2005 May. PMID 15834419

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings implicate NEU3 as a potential biomarker of insulin sensitivity, and provide novel mechanistic insight into the regulation of NEU3 expression.
      Title: NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids.
    2. activation of Neu3 sialidase is an essential step in regeneration occurring in PNS (sensory) but not CNS (retinal) axons
      Title: Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons.
    3. NEU3 participates in the control of insulin signaling via modulation of gangliosides and interaction with Grb2
      Title: Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-sialidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exo-alpha-sialidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exo-alpha-sialidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exo-alpha-sialidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sialidase-3
    Names
    N-acetyl-alpha-neuraminidase 3
    ganglioside sialidase
    membrane sialidase
    sialidase 3 (membrane sialidase)
    NP_001380602.1
    NP_446462.1
    XP_008757888.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393673.1 → NP_001380602.1  sialidase-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q497C0, Q99PW5
      UniProtKB/TrEMBL
      A6I6K4
      Conserved Domains (1) summary
      cd15482
      Location:11 → 402
      Sialidase_non-viral; Non-viral sialidases

    2. NM_054010.2 → NP_446462.1  sialidase-3

      See identical proteins and their annotated locations for NP_446462.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q497C0, Q99PW5
      UniProtKB/TrEMBL
      A6I6K4
      Related
      ENSRNOP00000098329.2, ENSRNOT00000120697.2
      Conserved Domains (1) summary
      cd15482
      Location:11 → 402
      Sialidase_non-viral; Non-viral sialidases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      163549834..163560997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759666.4 → XP_008757888.1  sialidase-3 isoform X1

      Conserved Domains (1) summary
      cd15482
      Location:2 → 334
      Sialidase_non-viral; Non-viral sialidases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PW5.1 GenPept UniProtKB/Swiss-Prot:Q99PW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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