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    VWF von Willebrand factor [ Canis lupus familiaris (dog) ]

    Gene ID: 399544, updated on 17-Aug-2024

    Summary

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    Official Symbol
    VWFprovided by VGNC
    Official Full Name
    von Willebrand factorprovided by VGNC
    Primary source
    VGNC:VGNC:48329
    See related
    Ensembl:ENSCAFG00845029798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    F8VWF
    Orthologs
    human mouse all
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    Genomic context

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    See VWF in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    54
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (39191850..39329540)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (7641828..7779174, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (7119622..7257688, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (39062625..39200071)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (39104190..39241989)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119866432 Neighboring gene uncharacterized LOC102157333 Neighboring gene CD9 molecule Neighboring gene anoctamin 2 Neighboring gene uncharacterized LOC111092786 Neighboring gene neurotrophin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel VWF variant associated with type 2 von Willebrand disease in German Wirehaired Pointers and German Shorthaired Pointers. Vos-Loohuis M, et al. Anim Genet, 2017 Aug. PMID 28696025
    2. Mutation causing von Willebrand's disease in Scottish Terriers. Venta PJ, et al. J Vet Intern Med, 2000 Jan-Feb. PMID 10668811
    3. [Expressions of CD31 and vWF in arachnoid villus endothelium cell from experimental animal with Hydrocephalus]. Wang ER, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2007 Jun. PMID 17593818
    4. Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells. Haberichter SL, et al. Blood, 2005 Jan 1. PMID 15331450, Free PMC Article
    5. von Willebrand factor storage and multimerization: 2 independent intracellular processes. Haberichter SL, et al. Blood, 2000 Sep 1. PMID 10961880

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. only the c.1657G variant was found in the homozygous state exclusively in Von Willebrand disease affected dogs, and this variant is the strongest candidate to be the cause of VWD type 2 in the German Wirehaired Pointer and German Shorthaired Pointer breeds
      Title: A novel VWF variant associated with type 2 von Willebrand disease in German Wirehaired Pointers and German Shorthaired Pointers.
    2. the CD-31 and vonWillebrand factor (vWF) expressions and the cell morphological alterations ofarachnoid villus endothelium in different stages of animal hydrocephalus
      Title: [Expressions of CD31 and vWF in arachnoid villus endothelium cell from experimental animal with Hydrocephalus].
    3. Expression of mutant VWF proteins confirmed that VWF multimerization is not necessary for Weibel-Palade body creation
      Title: Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    von Willebrand factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002932.1 → NP_001002932.1  von Willebrand factor precursor

      See identical proteins and their annotated locations for NP_001002932.1

      Status: PROVISIONAL

      Source sequence(s)
      U66246
      UniProtKB/TrEMBL
      A0A219Y8W3
      Related
      ENSCAFP00845041932.1, ENSCAFT00845053377.1
      Conserved Domains (13) summary
      smart00041
      Location:2727 → 2808
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:2261 → 2321
      VWC; von Willebrand factor (vWF) type C domain
      smart00216
      Location:377 → 540
      VWD; von Willebrand factor (vWF) type D domain
      smart00327
      Location:1277 → 1449
      VWA; von Willebrand factor (vWF) type A domain
      smart00832
      Location:1053 → 1127
      C8; This domain contains 8 conserved cysteine residues
      cd01450
      Location:1497 → 1645
      vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam00092
      Location:1691 → 1860
      VWA; von Willebrand factor type A domain
      pfam00093
      Location:2431 → 2494
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:35 → 179
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:652 → 707
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:2135 → 2199
      C8; C8 domain
      pfam16164
      Location:1198 → 1276
      VWA_N2; VWA N-terminal
      cl17735
      Location:2582 → 2644
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      39191850..39329540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038437724.1 → XP_038293652.1  von Willebrand factor isoform X1

      UniProtKB/TrEMBL
      A0A8I3SCK0
      Conserved Domains (13) summary
      smart00041
      Location:2731 → 2812
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:2265 → 2325
      VWC; von Willebrand factor (vWF) type C domain
      smart00216
      Location:381 → 544
      VWD; von Willebrand factor (vWF) type D domain
      smart00327
      Location:1281 → 1453
      VWA; von Willebrand factor (vWF) type A domain
      smart00832
      Location:1057 → 1131
      C8; This domain contains 8 conserved cysteine residues
      cd01450
      Location:1501 → 1649
      vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam00093
      Location:2435 → 2498
      VWC; von Willebrand factor type C domain
      cl17735
      Location:2586 → 2648
      VWC; von Willebrand factor type C domain
      pfam00092
      Location:1695 → 1864
      VWA; von Willebrand factor type A domain
      pfam00094
      Location:39 → 183
      VWD; von Willebrand factor type D domain
      pfam08742
      Location:2142 → 2203
      C8; C8 domain
      pfam16164
      Location:1202 → 1280
      VWA_N2; VWA N-terminal
      cd19941
      Location:656 → 711
      TIL; trypsin inhibitor-like cysteine rich domain

    RNA

    1. XR_005302758.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      39062625..39200071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      39104190..39241989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      7119622..7257688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      7641828..7779174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28295.2 GenPept UniProtKB/Swiss-Prot:Q28295

    Gene LinkOut

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