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    ESR1 estrogen receptor 1 [ Equus caballus (horse) ]

    Gene ID: 791249, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ESR1provided by VGNC
    Official Full Name
    estrogen receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:49449
    See related
    Ensembl:ENSECAG00000022441
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See ESR1 in Genome Data Viewer
    Location:
    chromosome: 31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 31 NC_009174.3 (15112682..15364616, complement)

    Chromosome 31 - NC_009174.3Genomic Context describing neighboring genes Neighboring gene MYC target 1 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene uncharacterized LOC106782930 Neighboring gene uncharacterized LOC111771397 Neighboring gene coiled-coil domain containing 170 Neighboring gene acidic residue methyltransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009174.3 Chromosome 31 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immunohistochemical localisation of progesterone and oestrogen receptors at the placental interface in mares during early pregnancy. Wilsher S, et al. Anim Reprod Sci, 2011 Dec. PMID 22176887
    2. Assignment of the horse progesterone receptor (PGR) and estrogen receptor (ESR1) genes to horse chromosomes 7 and 31, respectively, by in situ hybridization. Lear TL, et al. Cytogenet Cell Genet, 1998. PMID 9763674
    3. Stallion spermatozoa: putative target of estrogens; presence of the estrogen receptors ESR1, ESR2 and identification of the estrogen-membrane receptor GPER. Arkoun B, et al. Gen Comp Endocrinol, 2014 May 1. PMID 24607572
    4. Immunohistochemical localization of oestrogen receptors alpha and beta, progesterone receptor and aromatase in the equine placenta. Abd-Elnaeim MM, et al. Reprod Domest Anim, 2009 Apr. PMID 18992099
    5. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
      Title: Stallion spermatozoa: putative target of estrogens; presence of the estrogen receptors ESR1, ESR2 and identification of the estrogen-membrane receptor GPER.
    2. The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.
      Title: Immunohistochemical localisation of progesterone and oestrogen receptors at the placental interface in mares during early pregnancy.
    3. expression of estrogen receptor alpha and beta and progesterone receptor in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
      Title: Immunohistochemical localization of oestrogen receptors alpha and beta, progesterone receptor and aromatase in the equine placenta.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables estrogen response element binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to estrogen stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    estrogen receptor
    Names
    ER
    ER-alpha
    estradiol receptor
    estrogen receptor alpha
    nuclear receptor subfamily 3 group A member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081772.1 → NP_001075241.1  estrogen receptor

      See identical proteins and their annotated locations for NP_001075241.1

      Status: PROVISIONAL

      Source sequence(s)
      AF124093
      UniProtKB/Swiss-Prot
      Q9TV98
      Conserved Domains (4) summary
      cd06949
      Location:310 → 546
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180 → 261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:555 → 594
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009174.3 Reference EquCab3.0 Primary Assembly

      Range
      15112682..15364616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023632844.1 → XP_023488612.1  estrogen receptor isoform X1

      Conserved Domains (4) summary
      cd06949
      Location:325 → 562
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180 → 276
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:571 → 610
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    2. XM_023632845.1 → XP_023488613.1  estrogen receptor isoform X1

      Conserved Domains (4) summary
      cd06949
      Location:325 → 562
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180 → 276
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:571 → 610
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    3. XM_023632846.1 → XP_023488614.1  estrogen receptor isoform X1

      Conserved Domains (4) summary
      cd06949
      Location:325 → 562
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180 → 276
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:571 → 610
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    4. XM_023632847.1 → XP_023488615.1  estrogen receptor isoform X2

      UniProtKB/TrEMBL
      F6U1C9
      Related
      ENSECAP00000020141.2, ENSECAT00000024250.3
      Conserved Domains (4) summary
      cd06949
      Location:323 → 560
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180 → 274
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:569 → 608
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    5. XM_023632848.1 → XP_023488616.1  estrogen receptor isoform X3

      UniProtKB/TrEMBL
      F6UQ47
      Related
      ENSECAP00000020237.3, ENSECAT00000024366.4
      Conserved Domains (4) summary
      cd06949
      Location:312 → 549
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180 → 263
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:558 → 597
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    6. XM_023632849.1 → XP_023488617.1  estrogen receptor isoform X4

      Conserved Domains (3) summary
      cd07171
      Location:180 → 261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 181
      Oest_recep; Oestrogen receptor
      cl11397
      Location:325 → 471
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TV98.1 GenPept UniProtKB/Swiss-Prot:Q9TV98

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