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    SPAST spastin [ Monodelphis domestica (gray short-tailed opossum) ]

    Gene ID: 100026979, updated on 8-May-2024

    Summary

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    Gene symbol
    SPAST
    Gene description
    spastin
    See related
    EnsemblRapid:ENSMODG00000015479
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Monodelphis domestica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
    Orthologs
    human mouse all
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    Genomic context

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    See SPAST in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_05 current mMonDom1.pri (GCF_027887165.1) 1 NC_077227.1 (523580112..523682030)
    103 previous assembly MonDom5 (GCF_000002295.2) 1 NC_008801.1 (515396370..515497947)

    Chromosome 1 - NC_077227.1Genomic Context describing neighboring genes Neighboring gene mediator of cell motility 1 Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene SAP30 like Neighboring gene solute carrier family 30 member 6 Neighboring gene NLR family CARD domain containing 4 Neighboring gene Yip1 domain family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule severing ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spastin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_027887165.1-RS_2023_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mMonDom1.pri

    Genomic

    1. NC_077227.1 Reference mMonDom1.pri

      Range
      523580112..523682030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001371467.4 → XP_001371504.1  spastin isoform X1

      UniProtKB/TrEMBL
      A0A5F8HAG2, F6WWB5
      Related
      ENSMODP00000019317.4, ENSMODT00000019665.6
      Conserved Domains (5) summary
      smart00382
      Location:377 → 513
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:119 → 198
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:381 → 511
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:583 → 615
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:344 → 400
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_001371493.4 → XP_001371530.1  spastin isoform X3

      UniProtKB/TrEMBL
      A0A5F8HAG2, A0A5F8HE08
      Related
      ENSMODP00000058058.1, ENSMODT00000061472.2
      Conserved Domains (5) summary
      smart00382
      Location:345 → 481
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:119 → 198
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:349 → 479
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:551 → 583
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:312 → 368
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_007476044.3 → XP_007476106.1  spastin isoform X4

      UniProtKB/TrEMBL
      A0A5F8HAG2
      Conserved Domains (5) summary
      smart00382
      Location:344 → 480
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:119 → 197
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:348 → 478
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:550 → 582
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:311 → 367
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_007476043.3 → XP_007476105.1  spastin isoform X2

      UniProtKB/TrEMBL
      A0A5F8HAG2
      Conserved Domains (5) summary
      smart00382
      Location:376 → 512
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:119 → 197
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:380 → 510
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:582 → 614
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:343 → 399
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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