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    Thrap3 thyroid hormone receptor associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 230753, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Thrap3provided by MGI
    Official Full Name
    thyroid hormone receptor associated protein 3provided by MGI
    Primary source
    MGI:MGI:2442637
    See related
    Ensembl:ENSMUSG00000043962 AllianceGenome:MGI:2442637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trap150; 9330151F09Rik; B230333E16Rik
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Involved in circadian rhythm. Part of mediator complex. Is expressed in several structures, including brain; branchial arch; genitourinary system; limb; and retina nuclear layer. Orthologous to human THRAP3 (thyroid hormone receptor associated protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 45.1), limb E14.5 (RPKM 31.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Thrap3 in Genome Data Viewer
    Location:
    4 D2.2; 4 60.0 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126057875..126096548, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126164082..126202755, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene eva-1 homolog B Neighboring gene SH3 domain containing 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125839584-125839767 Neighboring gene STARR-seq mESC enhancer starr_11390 Neighboring gene STARR-seq mESC enhancer starr_11391 Neighboring gene STARR-seq mESC enhancer starr_11392 Neighboring gene predicted gene, 25323 Neighboring gene MAP7 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6217 Neighboring gene STARR-positive B cell enhancer ABC_E2122 Neighboring gene trafficking protein particle complex 3 Neighboring gene predicted gene, 54258

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate atherosclerosis by regulating c-FOS in vascular smooth muscle cells proliferation and migration. Zhang R, et al. Atherosclerosis, 2023 Aug. PMID 37549548
    2. Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy. Jang HJ, et al. Exp Mol Med, 2023 Aug. PMID 37524868, Free PMC Article
    3. Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming. Choi JH, et al. Genes Dev, 2014 Nov 1. PMID 25316675, Free PMC Article
    4. THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. Katano-Toki A, et al. Mol Endocrinol, 2013 May. PMID 23525231, Free PMC Article
    5. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis. Sono T, et al. J Bone Miner Metab, 2018 Jul. PMID 28770354

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate atherosclerosis by regulating c-FOS in vascular smooth muscle cells proliferation and migration.
      Title: LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate atherosclerosis by regulating c-FOS in vascular smooth muscle cells proliferation and migration.
    2. Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy.
      Title: Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy.
    3. These results indicate that THRAP3 negatively regulates SOX9 transcriptional activity as a cofactor of a SOX9 transcriptional complex during chondrogenesis.
      Title: THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis.
    4. Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARgamma-mediated gene activation cooperatively with Helz2.
      Title: THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation.
    5. TRAP150 is a selective coactivator for CLOCK-BMAL1, promoting its binding to target genes and linking it to the transcriptional machinery at target-gene promoters.
      Title: A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC37192, MGC56927, MGC98683, MGC116673

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear thyroid hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exon-exon junction complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    thyroid hormone receptor-associated protein 3
    Names
    thyroid hormone receptor-associated protein complex 150 kDa component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356455.1 → NP_001343384.1  thyroid hormone receptor-associated protein 3

      Status: VALIDATED

      Source sequence(s)
      AL732624, BB855884, BC092239
      Consensus CDS
      CCDS18645.1
      UniProtKB/Swiss-Prot
      Q569Z6
      Conserved Domains (1) summary
      pfam15440
      Location:191 → 766
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    2. NM_001356456.1 → NP_001343385.1  thyroid hormone receptor-associated protein 3

      Status: VALIDATED

      Source sequence(s)
      AL732624, BB855884, BC092239
      Consensus CDS
      CCDS18645.1
      UniProtKB/Swiss-Prot
      Q569Z6
      Conserved Domains (1) summary
      pfam15440
      Location:191 → 766
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    3. NM_146153.3 → NP_666265.3  thyroid hormone receptor-associated protein 3

      See identical proteins and their annotated locations for NP_666265.3

      Status: VALIDATED

      Source sequence(s)
      BC092239, BY327148
      Consensus CDS
      CCDS18645.1
      UniProtKB/Swiss-Prot
      Q569Z6
      Related
      ENSMUSP00000079722.6, ENSMUST00000080919.12
      Conserved Domains (1) summary
      pfam15440
      Location:191 → 766
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126057875..126096548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164049.1 → XP_036019942.1  thyroid hormone receptor-associated protein 3 isoform X2

      Conserved Domains (1) summary
      pfam15440
      Location:3 → 484
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    2. XM_036164048.1 → XP_036019941.1  thyroid hormone receptor-associated protein 3 isoform X2

      Conserved Domains (1) summary
      pfam15440
      Location:3 → 484
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    3. XM_036164047.1 → XP_036019940.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q569Z6
      Conserved Domains (1) summary
      pfam15440
      Location:191 → 766
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    RNA

    1. XR_003954927.1 RNA Sequence

    2. XR_003954926.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q569Z6.1 GenPept UniProtKB/Swiss-Prot:Q569Z6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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