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    Crnn cornulin [ Mus musculus (house mouse) ]

    Gene ID: 381457, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Crnnprovided by MGI
    Official Full Name
    cornulinprovided by MGI
    Primary source
    MGI:MGI:2685861
    See related
    Ensembl:ENSMUSG00000078657 AllianceGenome:MGI:2685861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1015
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cell cycle G1/S phase transition; and positive regulation of keratinocyte proliferation. Predicted to be located in cytoplasm and membrane. Is expressed in epidermis; esophagus epithelium; and nail. Orthologous to human CRNN (cornulin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Crnn in Genome Data Viewer
    Location:
    3 F2.1; 3 40.14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (93052096..93057125)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (93144789..93149818)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene TD and POZ domain containing 8 Neighboring gene predicted gene, 35785 Neighboring gene thymosin beta-10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08318 Neighboring gene filaggrin family member 2 Neighboring gene splicing factor 3a, subunit 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation. Contzler R, et al. J Invest Dermatol, 2005 May. PMID 15854041
    2. Trichohyalin-like proteins have evolutionarily conserved roles in the morphogenesis of skin appendages. Mlitz V, et al. J Invest Dermatol, 2014 Nov. PMID 24780931, Free PMC Article
    3. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cornulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081200.2 → NP_001074669.1  cornulin

      See identical proteins and their annotated locations for NP_001074669.1

      Status: VALIDATED

      Source sequence(s)
      AC135289
      Consensus CDS
      CCDS38524.1
      UniProtKB/TrEMBL
      D3YUU6
      Related
      ENSMUSP00000102921.2, ENSMUST00000107300.7
      Conserved Domains (2) summary
      cd00213
      Location:2 → 89
      S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
      pfam13499
      Location:28 → 75
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      93052096..93057125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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