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    alpk3b alpha-kinase 3b [ Danio rerio (zebrafish) ]

    Gene ID: 100534893, updated on 18-Sep-2024

    Summary

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    Official Symbol
    alpk3bprovided by ZNC
    Official Full Name
    alpha-kinase 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-121101-3
    See related
    Ensembl:ENSDARG00000105630 AllianceGenome:ZFIN:ZDB-GENE-121101-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in cardiac muscle cell development. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human ALPK3 (alpha kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See alpk3b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (30109978..30132422, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (29838835..29851620, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 3b Neighboring gene neuromedin Bb Neighboring gene FERM domain containing 5b Neighboring gene transmembrane p24 trafficking protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    2. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-kinase 3b; alpha-protein kinase 3
    XP_017212548.2
    XP_021327621.1
    XP_021333526.1
    XP_021333527.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      30109978..30132422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477852.2 → XP_021333527.1  alpha-protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PPS8
      Related
      ENSDARP00000142638.1, ENSDART00000173749.2
      Conserved Domains (4) summary
      pfam07679
      Location:62 → 154
      I-set; Immunoglobulin I-set domain
      pfam02816
      Location:1663 → 1860
      Alpha_kinase; Alpha-kinase family
      cd00096
      Location:1552 → 1606
      Ig; Immunoglobulin domain
      cl26511
      Location:280 → 829
      Neuromodulin_N; Gap junction protein N-terminal region

    2. XM_021477851.2 → XP_021333526.1  alpha-protein kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZ45
      Conserved Domains (4) summary
      pfam07679
      Location:75 → 167
      I-set; Immunoglobulin I-set domain
      pfam02816
      Location:1676 → 1873
      Alpha_kinase; Alpha-kinase family
      cd00096
      Location:1565 → 1619
      Ig; Immunoglobulin domain
      cl26511
      Location:293 → 842
      Neuromodulin_N; Gap junction protein N-terminal region

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394696.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      77947..100391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357059.3 → XP_017212548.2  alpha-protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PPS8
      Conserved Domains (4) summary
      pfam07679
      Location:62 → 154
      I-set; Immunoglobulin I-set domain
      pfam02816
      Location:1663 → 1860
      Alpha_kinase; Alpha-kinase family
      cd00096
      Location:1552 → 1606
      Ig; Immunoglobulin domain
      cl26511
      Location:280 → 829
      Neuromodulin_N; Gap junction protein N-terminal region

    2. XM_021471946.2 → XP_021327621.1  alpha-protein kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZ45
      Conserved Domains (4) summary
      pfam07679
      Location:75 → 167
      I-set; Immunoglobulin I-set domain
      pfam02816
      Location:1676 → 1873
      Alpha_kinase; Alpha-kinase family
      cd00096
      Location:1565 → 1619
      Ig; Immunoglobulin domain
      cl26511
      Location:293 → 842
      Neuromodulin_N; Gap junction protein N-terminal region
    Nucleotide Protein
    Heading Accession and Version

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