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    adap2 ArfGAP with dual PH domains 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100331455, updated on 2-Nov-2024

    Summary

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    Official Symbol
    adap2provided by ZNC
    Official Full Name
    ArfGAP with dual PH domains 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-21
    See related
    Ensembl:ENSDARG00000070565 AllianceGenome:ZFIN:ZDB-GENE-070912-21
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-33i10.5; si:ch211-11k18.11
    Summary
    Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Acts upstream of or within atrioventricular valve development; heart jogging; and heart looping. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. Is expressed in several structures, including digestive system; gonad; head; heart; and skeletal muscle. Orthologous to human ADAP2 (ArfGAP with dual PH domains 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See adap2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26267727..26281815)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26136021..26151762)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 4, catalytic subunit a Neighboring gene ATPase family AAA domain containing 5a Neighboring gene ras homolog family member T1a Neighboring gene uncharacterized LOC100331676

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ADAP2 in heart development: a candidate gene for the occurrence of cardiovascular malformations in NF1 microdeletion syndrome. Venturin M, et al. J Med Genet, 2014 Jul. PMID 24711647
    2. Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio). Chen X, et al. Sci Total Environ, 2021 Sep 15. PMID 33991914
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within atrioventricular valve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart jogging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with dual PH domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      26267727..26281815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473800.2 → XP_021329475.1  arf-GAP with dual PH domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q881
      Conserved Domains (3) summary
      cd01251
      Location:254 → 361
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:134 → 240
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
      pfam01412
      Location:8 → 123
      ArfGap; Putative GTPase activating protein for Arf

    2. XM_021473801.2 → XP_021329476.1  arf-GAP with dual PH domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q439, E9QE78
      Related
      ENSDARP00000119626.1, ENSDART00000131288.2
      Conserved Domains (3) summary
      cd01251
      Location:254 → 361
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:134 → 240
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
      pfam01412
      Location:8 → 123
      ArfGap; Putative GTPase activating protein for Arf
    Nucleotide Protein
    Heading Accession and Version

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