U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    tnfrsf19 tumor necrosis factor receptor superfamily, member 19 [ Danio rerio (zebrafish) ]

    Gene ID: 559725, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tnfrsf19provided by ZNC
    Official Full Name
    tumor necrosis factor receptor superfamily, member 19provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6760
    See related
    Ensembl:ENSDARG00000041869 AllianceGenome:ZFIN:ZDB-GENE-030131-6760
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    troy; fa04d10; wu:fa04d10; wu:fk80e07; zgc:136805; si:ch211-113p18.2
    Summary
    Predicted to enable signaling receptor activity. Acts upstream of or within establishment of endothelial blood-brain barrier; posterior lateral line neuromast deposition; and sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in otic vesicle; posterior lateral line primordium; and tectal ventricle. Orthologous to human TNFRSF19 (TNF receptor superfamily member 19). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tnfrsf19 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (8235531..8309218, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (8259460..8333154, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene cell adhesion molecule 2b Neighboring gene BTB and CNC homology 1, basic leucine zipper transcription factor 1 a Neighboring gene mitochondrial intermediate peptidase a Neighboring gene si:ch211-113p18.3 Neighboring gene egl-9 family hypoxia-inducible factor 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. No Nogo66- and NgR-mediated inhibition of regenerating axons in the zebrafish optic nerve. Abdesselem H, et al. J Neurosci, 2009 Dec 9. PMID 20007473, Free PMC Article
    2. CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development. Huang S, et al. Genes (Basel), 2023 Apr 28. PMID 37239365, Free PMC Article
    3. The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor. Han HW, et al. PLoS One, 2014. PMID 24466042, Free PMC Article
    4. Death receptors DR6 and TROY regulate brain vascular development. Tam SJ, et al. Dev Cell, 2012 Feb 14. PMID 22340501
    5. Dydrogesterone Causes Male Bias and Accelerates Sperm Maturation in Zebrafish ( Danio rerio). Shi WJ, et al. Environ Sci Technol, 2018 Aug 7. PMID 30004691

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC136805

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of endothelial blood-brain barrier IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of endothelial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within posterior lateral line development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within posterior lateral line neuromast deposition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tumor necrosis factor receptor superfamily member 19

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044904.1 → NP_001038369.1  tumor necrosis factor receptor superfamily member 19 precursor

      See identical proteins and their annotated locations for NP_001038369.1

      Status: PROVISIONAL

      Source sequence(s)
      BC117651
      UniProtKB/TrEMBL
      B1N8Y3, F6NRJ5, Q1ECV9
      Related
      ENSDARP00000061350.5, ENSDART00000061351.7
      Conserved Domains (1) summary
      cd13418
      Location:33 → 149
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      8235531..8309218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017350963.3 → XP_017206452.1  tumor necrosis factor receptor superfamily member 19 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YT06

    2. XM_021481422.2 → XP_021337097.1  tumor necrosis factor receptor superfamily member 19 isoform X1

      UniProtKB/TrEMBL
      B1N8Y3, F6NRJ5, Q1ECV9
      Conserved Domains (1) summary
      cd13418
      Location:33 → 149
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

    3. XM_021481423.2 → XP_021337098.1  tumor necrosis factor receptor superfamily member 19 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QC14
      Conserved Domains (1) summary
      cd13418
      Location:7 → 123
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous