casr calcium-sensing receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: casrprovided by ZNC
Official Full Name: calcium-sensing receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050119-8
See related: Ensembl:ENSDARG00000013649 AllianceGenome:ZFIN:ZDB-GENE-050119-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: casrl
Summary: Predicted to enable G protein-coupled receptor activity and metal ion binding activity. Acts upstream of or within calcium ion homeostasis and skeletal system development. Predicted to be located in plasma membrane. Is expressed in several structures, including head; integument; nervous system; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (67768162..67783593, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (67089793..67101393, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrates that CaSR promotes sensorimotor decision making acutely through Galphai/o and Galphaq/11 signaling, modulated by clathrin-mediated endocytosis.
Title: A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making.
the results suggest that the CaSR is critical for Ca(2+) homeostasis in larval zebrafish exposed to low environmental Ca(2+) levels, possibly owing to its modulation of stanniocalcin mRNA expression.
Title: Involvement of the calcium-sensing receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium.
CaSR is essential in skeletogenesis in fishes.
Title: Morpholino oligonucleotide knockdown of the extracellular calcium-sensing receptor impairs early skeletal development in zebrafish.
Calcium-sensing receptor has a role in mediating Ca(2+) homeostasis by modulating expression of PTH and stanniocalcin
Title: Calcium-sensing receptor mediates Ca(2+) homeostasis by modulating expression of PTH and stanniocalcin.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: extracellular calcium-sensing receptor

Names: zmp:0000001046

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001351665.1 → NP_001338594.1 extracellular calcium-sensing receptor precursor

Status: VALIDATED

Source sequence(s)

FQ790224, LO017805

UniProtKB/TrEMBL

A0A8M1P4E9

Related

ENSDARP00000013946.9, ENSDART00000010934.10

Conserved Domains (4) summary

pfam07562
Location:529 → 580

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd14964
Location:601 → 625

7tm_GPCRs; TM helix 1 [structural motif]

cl10011
Location:24 → 519

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl28897
Location:600 → 850

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily