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    Amotl2 angiomotin-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 56332, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Amotl2provided by MGI
    Official Full Name
    angiomotin-like 2provided by MGI
    Primary source
    MGI:MGI:1929286
    See related
    Ensembl:ENSMUSG00000032531 AllianceGenome:MGI:1929286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lccp; MASCOT; mKIAA0989
    Summary
    Enables actin filament binding activity and identical protein binding activity. Involved in endothelial cell morphogenesis. Located in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including brain ventricular layer; dorsal aorta; gonad; telencephalon; and trophectoderm. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in adrenal adult (RPKM 51.4), lung adult (RPKM 30.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Amotl2 in Genome Data Viewer
    Location:
    9 F1; 9 54.71 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (102594290..102610616)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (102717091..102733418)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 63 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:102528825-102529014 Neighboring gene anaphase promoting complex subunit 13 Neighboring gene VISTA enhancer mm1302 Neighboring gene STARR-seq mESC enhancer starr_25068 Neighboring gene predicted gene, 46150 Neighboring gene STARR-seq mESC enhancer starr_25069 Neighboring gene predicted gene 5627 Neighboring gene predicted gene, 46151

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation. Fang P, et al. Environ Toxicol, 2021 Nov. PMID 34323359
    2. AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion. Mojallal M, et al. Nat Commun, 2014 Aug 1. PMID 25080976
    3. Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. Wang Y, et al. J Biol Chem, 2011 Nov 25. PMID 21937427, Free PMC Article
    4. Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation. Matsumoto H, et al. J Reprod Dev, 2012. PMID 22813598
    5. The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms. Zhang Y, et al. Nat Cardiovasc Res, 2023 Jul. PMID 39195920, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.
      Title: The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.
    2. AMOTL2 restrains transforming growth factor-beta1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
      Title: AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
    3. mTORC2-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP signaling.
      Title: Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.
    4. AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
      Title: AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
    5. Amot, Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri-implantation period.
      Title: Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation.
    6. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
      Title: Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis.
    7. Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1.
      Title: Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity involved in ameboidal cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    angiomotin-like protein 2
    Names
    Leman coiled-coil protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421298.1 → NP_001408227.1  angiomotin-like protein 2

      Status: VALIDATED

      Source sequence(s)
      CT573150
      UniProtKB/Swiss-Prot
      B8JK80, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q8K371, Q9QUS0

    2. NM_001421301.1 → NP_001408230.1  angiomotin-like protein 2

      Status: VALIDATED

      Source sequence(s)
      CT573150
      UniProtKB/Swiss-Prot
      B8JK80, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q8K371, Q9QUS0
      Related
      ENSMUSP00000121113.2, ENSMUST00000153965.8

    3. NM_019764.2 → NP_062738.2  angiomotin-like protein 2

      See identical proteins and their annotated locations for NP_062738.2

      Status: VALIDATED

      Source sequence(s)
      AK141348, BB726257
      Consensus CDS
      CCDS40745.1
      UniProtKB/Swiss-Prot
      B8JK80, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q8K371, Q9QUS0
      UniProtKB/TrEMBL
      B8JK87
      Related
      ENSMUSP00000035121.8, ENSMUST00000035121.14
      Conserved Domains (2) summary
      COG1196
      Location:301 → 578
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:478 → 679
      Angiomotin_C; Angiomotin C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      102594290..102610616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511772.4 → XP_006511835.1  angiomotin-like protein 2 isoform X2

      UniProtKB/TrEMBL
      B8JK87
      Conserved Domains (2) summary
      COG1196
      Location:324 → 601
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:501 → 702
      Angiomotin_C; Angiomotin C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K371.1 GenPept UniProtKB/Swiss-Prot:Q8K371

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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