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    KLK5 kallikrein related peptidase 5 [ Homo sapiens (human) ]

    Gene ID: 25818, updated on 2-Nov-2024

    Summary

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    Official Symbol
    KLK5provided by HGNC
    Official Full Name
    kallikrein related peptidase 5provided by HGNC
    Primary source
    HGNC:HGNC:6366
    See related
    Ensembl:ENSG00000167754 MIM:605643; AllianceGenome:HGNC:6366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCTE; KLKL2; KLK-L2
    Summary
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 70.7), lung (RPKM 6.1) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See KLK5 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (50943303..50953038, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54031364..54041157, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51446559..51456294, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 4 Neighboring gene peptidylprolyl isomerase A pseudogene 59 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51442294-51442457 Neighboring gene uncharacterized LOC105372442 Neighboring gene kallikrein related peptidase 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51486908-51487462 Neighboring gene kallikrein related peptidase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria. Grzanka A, et al. J Biol Regul Homeost Agents, 2017 Apr-Jun. PMID 28685545
    2. Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival. Dorn J, et al. Ann Oncol, 2011 Aug. PMID 21273346
    3. Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response. Bandiera E, et al. Int J Gynecol Cancer, 2009 Aug. PMID 19820362
    4. Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer. Bayani J, et al. Mol Oncol, 2008 Oct. PMID 19383346, Free PMC Article
    5. The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. Pampalakis G, et al. Oncotarget, 2014 May 15. PMID 24158494, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation.
      Title: The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation.
    2. MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5.
      Title: MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5.
    3. Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
      Title: Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
    4. KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
      Title: KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
    5. Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.
      Title: Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.
    6. Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
      Title: Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
    7. Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition.
      Title: Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition.
    8. Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium.
      Title: Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium.
    9. Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
      Title: Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
    10. PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
      Title: PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amelogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cornification TAS
    Traceable Author Statement
    more info
    		  
    involved_in epidermis development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in extracellular matrix disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of antibacterial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in epidermal lamellar body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kallikrein-5
    Names
    kallikrein-like protein 2
    stratum corneum tryptic enzyme

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077491.2 → NP_001070959.1  kallikrein-5 preproprotein

      See identical proteins and their annotated locations for NP_001070959.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AY279381, AY359010
      Consensus CDS
      CCDS12810.1
      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Related
      ENSP00000375685.1, ENST00000391809.6
      Conserved Domains (1) summary
      smart00020
      Location:66 → 285
      Tryp_SPc; Trypsin-like serine protease

    2. NM_001077492.2 → NP_001070960.1  kallikrein-5 preproprotein

      See identical proteins and their annotated locations for NP_001070960.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AY359010
      Consensus CDS
      CCDS12810.1
      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Related
      ENSP00000471966.1, ENST00000593428.5
      Conserved Domains (1) summary
      smart00020
      Location:66 → 285
      Tryp_SPc; Trypsin-like serine protease

    3. NM_012427.5 → NP_036559.1  kallikrein-5 preproprotein

      See identical proteins and their annotated locations for NP_036559.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AY359010
      Consensus CDS
      CCDS12810.1
      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Related
      ENSP00000337733.2, ENST00000336334.8
      Conserved Domains (1) summary
      smart00020
      Location:66 → 285
      Tryp_SPc; Trypsin-like serine protease

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      50943303..50953038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526702.2 → XP_011525004.1  kallikrein-5 isoform X1

      See identical proteins and their annotated locations for XP_011525004.1

      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Conserved Domains (1) summary
      smart00020
      Location:66 → 285
      Tryp_SPc; Trypsin-like serine protease

    2. XM_011526703.3 → XP_011525005.1  kallikrein-5 isoform X1

      See identical proteins and their annotated locations for XP_011525005.1

      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Conserved Domains (1) summary
      smart00020
      Location:66 → 285
      Tryp_SPc; Trypsin-like serine protease

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54031364..54041157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320472.1 → XP_054176447.1  kallikrein-5 isoform X1

      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337

    2. XM_054320473.1 → XP_054176448.1  kallikrein-5 isoform X1

      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y337.3 GenPept UniProtKB/Swiss-Prot:Q9Y337

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