PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIK3CBprovided by HGNC
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaprovided by HGNC
Primary source: HGNC:HGNC:8976
See related: Ensembl:ENSG00000051382 MIM:602925; AllianceGenome:HGNC:8976
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PI3K; PIK3C1; P110BETA; PI3KBETA
Summary: This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Expression: Ubiquitous expression in thyroid (RPKM 19.2), kidney (RPKM 9.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q22.3

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (138652698..138834928, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (141393413..141575643, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (138371540..138553770, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of multiple myeloma cells.
Title: PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of multiple myeloma cells.
PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis.
Title: PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis.
Molecular dissection of PI3Kbeta synergistic activation by receptor tyrosine kinases, GbetaGgamma, and Rho-family GTPases.
Title: Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases.
HMGB1/PTEN/PI3K axis participates in the peripheral immune cell differentiation in two representative TCM syndromes of chronic hepatitis B patients.
Title: HMGB1/PTEN/PI3K axis participates in the peripheral immune cell differentiation in two representative TCM syndromes of chronic hepatitis B patients.
AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20).
Title: AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20).
Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma.
Title: Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma.
PI3Kbeta-regulated beta-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression.
Title: PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression.
Suppression of PI3Kp110beta Reduces Cell Viability and Induces Apoptosis in Human Esophageal Cancer.
Title: Suppression of PI3Kp110β Reduces Cell Viability and Induces Apoptosis in Human Esophageal Cancer.
CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells.
Title: CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells.
PIP3 abundance overcomes PI3K signaling selectivity in invadopodia.
Title: PIP(3) abundance overcomes PI3K signaling selectivity in invadopodia.

Submit: New GeneRIF Correction See all GeneRIFs (138)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes	PubMed
	env	HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors	PubMed
	env	CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn	PubMed
	env	Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production	PubMed
	env	Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling	PubMed
	env	CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity	PubMed
	env	PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells	PubMed
Nef	nef	HIV-1 Nef interacts with AKT1 and PI3K via its C and N terminal extremity, respectively	PubMed
	nef	HIV-1 Nef activation of AKT1 is mediated by PI3K in peripheral blood lymphocytes	PubMed
	nef	HIV-1 Nef involves the PI3K-PKC pathway for induction of IL6 and CXCL8 (IL8) expression	PubMed
	nef	HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells	PubMed
	nef	Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K	PubMed
	nef	In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase	PubMed
	nef	The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production	PubMed
	nef	The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression	PubMed
Tat	tat	HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells	PubMed
	tat	HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells	PubMed
	tat	PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells	PubMed
	tat	Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation	PubMed
	tat	HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K)	PubMed
	tat	Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway	PubMed
	tat	HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis	PubMed
	tat	Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex	PubMed
	tat	HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase	PubMed
	tat	Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase	PubMed
Vpr	vpr	HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes	PubMed
	vpr	HIV-1 Vpr induced upregulation of CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-14619 (e-PCR)
- UniSTS:23063

RH12673 (e-PCR)
- UniSTS:69144

SHGC-63 (e-PCR)
- UniSTS:86566

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	TAS Traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS Traceable Author Statement more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in angiogenesis involved in wound healing	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in embryonic cleavage	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular endothelial growth factor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet activation	TAS Traceable Author Statement more info	PubMed
involved_in platelet aggregation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of Rac protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of autophagy	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of clathrin-dependent endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in response to ischemia	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in sphingosine-1-phosphate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in midbody	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	IPI Inferred from Physical Interaction more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Names: PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K-beta; PtdIns-3-kinase p110; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB

NP_001242974.1

EC 2.7.1.153

EC 2.7.11.1

NP_006210.1

EC 2.7.1.153

EC 2.7.11.1

XP_006713722.1

EC 2.7.1.153

EC 2.7.11.1

XP_011511197.1

EC 2.7.1.153

EC 2.7.11.1

XP_016862108.1

EC 2.7.1.153

EC 2.7.11.1

XP_047304263.1

EC 2.7.1.153

EC 2.7.11.1

XP_047304264.1

EC 2.7.1.153

EC 2.7.11.1

XP_047304265.1

EC 2.7.1.153

EC 2.7.11.1

XP_047304266.1

EC 2.7.1.153

EC 2.7.11.1

XP_047304267.1

EC 2.7.1.153

EC 2.7.11.1

XP_047304268.1

EC 2.7.1.153

EC 2.7.11.1

XP_047304269.1

EC 2.7.1.153

EC 2.7.11.1

XP_047304270.1

EC 2.7.1.153

EC 2.7.11.1

XP_047304271.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202824.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202825.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202826.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202827.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202828.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202829.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202830.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202831.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202832.1

EC 2.7.1.153

EC 2.7.11.1

XP_054202833.1

EC 2.7.1.153

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256045.2 → NP_001242974.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC020890, AC117389, AI623206, AK293754

UniProtKB/TrEMBL

B4DER4

Related

ENSP00000438259.1, ENST00000544716.5

Conserved Domains (3) summary

cd00872
Location:44 → 214

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05173
Location:218 → 579

PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

cl14603
Location:1 → 30

C2; C2 domain
NM_006219.3 → NP_006210.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1

See identical proteins and their annotated locations for NP_006210.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represent the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AC020890, AC067728, AC117389, AI623206, BC114432

Consensus CDS

CCDS3104.1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2

Related

ENSP00000501150.1, ENST00000674063.1

Conserved Domains (5) summary

cd08693
Location:324 → 501

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00143
Location:41 → 118

PI3K_p85B; PI3-kinase family, p85-binding domain

smart00144
Location:180 → 288

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:532 → 702

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05173
Location:706 → 1067

PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

138652698..138834928 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448312.1 → XP_047304268.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_006713659.4 → XP_006713722.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

See identical proteins and their annotated locations for XP_006713722.1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2

Related

ENSP00000418143.1, ENST00000477593.6

Conserved Domains (5) summary

cd08693
Location:324 → 501

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00143
Location:41 → 118

PI3K_p85B; PI3-kinase family, p85-binding domain

smart00144
Location:180 → 288

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:532 → 702

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05173
Location:706 → 1067

PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
XM_047448311.1 → XP_047304267.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_047448314.1 → XP_047304270.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_011512895.3 → XP_011511197.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

See identical proteins and their annotated locations for XP_011511197.1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2

Conserved Domains (5) summary

cd08693
Location:324 → 501

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00143
Location:41 → 118

PI3K_p85B; PI3-kinase family, p85-binding domain

smart00144
Location:180 → 288

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:532 → 702

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05173
Location:706 → 1067

PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
XM_047448307.1 → XP_047304263.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2
XM_047448313.1 → XP_047304269.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_047448308.1 → XP_047304264.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2
XM_047448309.1 → XP_047304265.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2
XM_047448310.1 → XP_047304266.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2
XM_017006619.2 → XP_016862108.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2

Related

ENSP00000289153.2, ENST00000289153.6

Conserved Domains (5) summary

cd08693
Location:324 → 501

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00143
Location:41 → 118

PI3K_p85B; PI3-kinase family, p85-binding domain

smart00144
Location:180 → 288

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:532 → 702

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05173
Location:706 → 1067

PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
XM_047448315.1 → XP_047304271.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

141393413..141575643 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054346855.1 → XP_054202830.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_054346850.1 → XP_054202825.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2
XM_054346854.1 → XP_054202829.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_054346856.1 → XP_054202831.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_054346849.1 → XP_054202824.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2
XM_054346857.1 → XP_054202832.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_054346852.1 → XP_054202827.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2
XM_054346851.1 → XP_054202826.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2
XM_054346853.1 → XP_054202828.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

D3DNF0, P42338, Q24JU2
XM_054346858.1 → XP_054202833.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3