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    Gsta3 glutathione S-transferase, alpha 3 [ Mus musculus (house mouse) ]

    Gene ID: 14859, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gsta3provided by MGI
    Official Full Name
    glutathione S-transferase, alpha 3provided by MGI
    Primary source
    MGI:MGI:95856
    See related
    Ensembl:ENSMUSG00000025934 AllianceGenome:MGI:95856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gst2-3
    Summary
    Enables glutathione transferase activity. Involved in ureteric bud development. Acts upstream of or within aflatoxin catabolic process. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; liver; nervous system; nose; and urinary system. Orthologous to human GSTA3 (glutathione S-transferase alpha 3) and GSTA5 (glutathione S-transferase alpha 5). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in liver E18 (RPKM 172.7), liver adult (RPKM 140.8) and 8 other tissues See more
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    Genomic context

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    See Gsta3 in Genome Data Viewer
    Location:
    1 A4; 1 6.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (21310837..21335885)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (21240565..21265575)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene translocating chain-associating membrane protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:21030259-21030560 Neighboring gene STARR-seq mESC enhancer starr_00399 Neighboring gene transmembrane protein 14A Neighboring gene STARR-seq mESC enhancer starr_00401 Neighboring gene STARR-seq mESC enhancer starr_00402 Neighboring gene predicted gene, 32947 Neighboring gene predicted gene 28836 Neighboring gene STARR-seq mESC enhancer starr_00405 Neighboring gene STARR-seq mESC enhancer starr_00406 Neighboring gene predicted pseudogene 7094 Neighboring gene predicted gene 4956

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide. Hayes JD, et al. Biochem J, 1992 Jul 1. PMID 1637297, Free PMC Article
    2. Participation of liver stem cells in cholangiocarcinogenesis after aflatoxin B(1) exposure of glutathione S-transferase A3 knockout mice. Ilic Z, et al. Tumour Biol, 2018 May. PMID 29804515
    3. Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice. Crawford DR, et al. Carcinogenesis, 2017 Jul 1. PMID 28535182, Free PMC Article
    4. Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2. Jowsey IR, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14652005
    5. Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver. McLellan LI, et al. Biochem J, 1991 Jun 1. PMID 2049074, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. aflatoxin B1 induces cholangiocarcinomas in GSTA3-/- mice
      Title: Participation of liver stem cells in cholangiocarcinogenesis after aflatoxin B(1) exposure of glutathione S-transferase A3 knockout mice.
    2. There were no significant compensatory changes in KO mice GST subunits, GST enzymatic activity, epoxide hydrolase, or CYP1A2 and CYP3A11 levels. Finally, there was a modest increase in F2-isoprostane and isofuran in KO mice that confirmed putative GSTA3 hydroperoxidase activity in vivo for the first time.
      Title: Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice.
    3. Reporter gene assays demonstrated that mouse GSTA3 5(')-upstream region is activated by 15-deoxy-Delta(12,14)-prostaglandin J2 through an antioxidant response element, and that this may be involved in regulating GSTA3 expression during adipogenesis.
      Title: Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aflatoxin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ureteric bud development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase A3
    Names
    GST class-alpha member 3
    glutathione S-transferase Ya3
    glutathione S-transferase Yc
    NP_001070821.1
    NP_001275546.1
    NP_001407119.1
    NP_001407120.1
    NP_001407121.1
    NP_001407122.1
    NP_001407123.1
    NP_001407124.1
    NP_034486.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077353.3 → NP_001070821.1  glutathione S-transferase A3 isoform a

      See identical proteins and their annotated locations for NP_001070821.1

      Status: VALIDATED

      Source sequence(s)
      AC163025
      Consensus CDS
      CCDS14847.1
      UniProtKB/Swiss-Prot
      P30115, Q544Y6
      UniProtKB/TrEMBL
      Q9DCU1
      Related
      ENSMUSP00000113262.2, ENSMUST00000121676.8
      Conserved Domains (3) summary
      PTZ00057
      Location:1 → 198
      PTZ00057; glutathione s-transferase; Provisional
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. NM_001288617.2 → NP_001275546.1  glutathione S-transferase A3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC163025
      Conserved Domains (2) summary
      cd03208
      Location:36 → 170
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cl00388
      Location:1 → 32
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_001420190.1 → NP_001407119.1  glutathione S-transferase A3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC163025

    4. NM_001420191.1 → NP_001407120.1  glutathione S-transferase A3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC163025

    5. NM_001420192.1 → NP_001407121.1  glutathione S-transferase A3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC163025

    6. NM_001420193.1 → NP_001407122.1  glutathione S-transferase A3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC163025

    7. NM_001420194.1 → NP_001407123.1  glutathione S-transferase A3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC163025

    8. NM_001420195.1 → NP_001407124.1  glutathione S-transferase A3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC163025

    9. NM_010356.5 → NP_034486.2  glutathione S-transferase A3 isoform a

      See identical proteins and their annotated locations for NP_034486.2

      Status: VALIDATED

      Source sequence(s)
      AC163025
      Consensus CDS
      CCDS14847.1
      UniProtKB/Swiss-Prot
      P30115, Q544Y6
      UniProtKB/TrEMBL
      Q9DCU1
      Related
      ENSMUSP00000027067.9, ENSMUST00000027067.15
      Conserved Domains (3) summary
      PTZ00057
      Location:1 → 198
      PTZ00057; glutathione s-transferase; Provisional
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      21310837..21335885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30115.2 GenPept UniProtKB/Swiss-Prot:P30115

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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