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    MCUB mitochondrial calcium uniporter dominant negative subunit beta [ Bos taurus (domestic cattle) ]

    Gene ID: 504728, updated on 4-Oct-2024

    Summary

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    Official Symbol
    MCUBprovided by VGNC
    Official Full Name
    mitochondrial calcium uniporter dominant negative subunit betaprovided by VGNC
    Primary source
    VGNC:VGNC:31326
    See related
    BGD:BT13185; Ensembl:ENSBTAG00000012995
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MCUB in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (15717831..15813163, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group XIIA Neighboring gene caspase 6 Neighboring gene SEC24 homolog B, COPII coat complex component Neighboring gene elongin-C-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC128209

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of uniplex complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium uniporter regulatory subunit MCUb, mitochondrial
    Names
    mitochondrial calcium uniporter dominant negative beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075171.2 → NP_001068639.1  calcium uniporter regulatory subunit MCUb, mitochondrial

      See identical proteins and their annotated locations for NP_001068639.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103005
      UniProtKB/TrEMBL
      A0AAA9SSX6, Q3ZBZ7
      Related
      ENSBTAP00000017276.6, ENSBTAT00000017276.7
      Conserved Domains (1) summary
      pfam04678
      Location:101 → 304
      MCU; Mitochondrial calcium uniporter

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      15717831..15813163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993091.2 → XP_024848859.1  calcium uniporter regulatory subunit MCUb, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0AAA9SSX6
      Conserved Domains (1) summary
      pfam04678
      Location:102 → 269
      MCU; Mitochondrial calcium uniporter

    2. XM_024993090.2 → XP_024848858.1  calcium uniporter regulatory subunit MCUb, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LPW1, F6QZT1
      Related
      ENSBTAP00000059050.1, ENSBTAT00000082042.2
      Conserved Domains (1) summary
      pfam04678
      Location:71 → 273
      MCU; Mitochondrial calcium uniporter
    Nucleotide Protein Strain
    Heading Accession and Version

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