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    TMEM35A transmembrane protein 35A [ Homo sapiens (human) ]

    Gene ID: 59353, updated on 2-Nov-2024

    Summary

    Official Symbol
    TMEM35Aprovided by HGNC
    Official Full Name
    transmembrane protein 35Aprovided by HGNC
    Primary source
    HGNC:HGNC:25864
    See related
    Ensembl:ENSG00000126950 AllianceGenome:HGNC:25864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NACHO; TUF-1; TMEM35
    Summary
    Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 18.3), prostate (RPKM 12.0) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TMEM35A in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (101078879..101096367)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99522299..99539787)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100333868..100351356)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 13A Neighboring gene ReSE screen-validated silencer GRCh37_chrX:100246331-100246526 Neighboring gene tRNA methyltransferase 2 homolog B Neighboring gene uncharacterized LOC124905285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29807 Neighboring gene centromere protein I Neighboring gene YWHAQ pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14084

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetylcholine receptor regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine receptor regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    novel acetylcholine receptor chaperone
    Names
    nAChR regulator
    nicotinic acetylcholine receptor regulator
    transmembrane protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021637.3NP_067650.1  novel acetylcholine receptor chaperone

      See identical proteins and their annotated locations for NP_067650.1

      Status: VALIDATED

      Source sequence(s)
      AL109952, BC078658, BU736545
      Consensus CDS
      CCDS14478.1
      UniProtKB/Swiss-Prot
      Q53FP2, Q9H7Y3
      Related
      ENSP00000362021.4, ENST00000372930.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      101078879..101096367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      99522299..99539787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)