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    Arsg arylsulfatase G [ Mus musculus (house mouse) ]

    Gene ID: 74008, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arsgprovided by MGI
    Official Full Name
    arylsulfatase Gprovided by MGI
    Primary source
    MGI:MGI:1921258
    See related
    Ensembl:ENSMUSG00000020604 AllianceGenome:MGI:1921258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ASG; 6330406P08Rik
    Summary
    Enables N-sulfoglucosamine-3-sulfatase activity and arylsulfatase activity. Acts upstream of or within several processes, including lysosome organization; neuron apoptotic process; and retina development in camera-type eye. Located in lysosome. Is expressed in central nervous system and retina. Used to study mucopolysaccharidosis. Human ortholog(s) of this gene implicated in Usher syndrome. Orthologous to human ARSG (arylsulfatase G). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 4.8), kidney adult (RPKM 3.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arsg in Genome Data Viewer
    Location:
    11 E1; 11 71.98 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109364159..109464156)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109473333..109573330)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109287298-109287521 Neighboring gene STARR-positive B cell enhancer ABC_E380 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109293875-109294028 Neighboring gene STARR-positive B cell enhancer ABC_E10727 Neighboring gene STARR-positive B cell enhancer ABC_E5293 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene predicted gene, 45916 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E5294 Neighboring gene STARR-positive B cell enhancer ABC_E7088 Neighboring gene STARR-positive B cell enhancer ABC_E1846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109357315-109357468 Neighboring gene predicted gene, 22378 Neighboring gene STARR-positive B cell enhancer ABC_E7089 Neighboring gene predicted gene, 39442 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene STARR-positive B cell enhancer ABC_E259 Neighboring gene STARR-positive B cell enhancer ABC_E11498 Neighboring gene predicted gene 11685 Neighboring gene STARR-seq mESC enhancer starr_31024

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient Mice. Kruszewski K, et al. Invest Ophthalmol Vis Sci, 2016 Mar. PMID 26975023
    2. Ataxia is the major neuropathological finding in arylsulfatase G-deficient mice: similarities and dissimilarities to Sanfilippo disease (mucopolysaccharidosis type III). Kowalewski B, et al. Hum Mol Genet, 2015 Apr 1. PMID 25452429, Free PMC Article
    3. Molecular characterization of arylsulfatase G: expression, processing, glycosylation, transport, and activity. Kowalewski B, et al. J Biol Chem, 2014 Oct 3. PMID 25135642, Free PMC Article
    4. Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Kowalewski B, et al. Proc Natl Acad Sci U S A, 2012 Jun 26. PMID 22689975, Free PMC Article
    5. Quantitative trait locus that determines the cross-sectional shape of the femur in SAMP6 and SAMP2 mice. Otsuki B, et al. J Bone Miner Res, 2007 May. PMID 17295603

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arsg knockout mice share common neuropathological findings with Sanfilippo syndrome animal models.
      Title: Ataxia is the major neuropathological finding in arylsulfatase G-deficient mice: similarities and dissimilarities to Sanfilippo disease (mucopolysaccharidosis type III).
    2. ARSG is differentially expressed, processed, and transported in tissues involving a membrane-associated pre-lysosomal precursor.
      Title: Molecular characterization of arylsulfatase G: expression, processing, glycosylation, transport, and activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90567

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-sulfoglucosamine-3-sulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables N-sulfoglucosamine-3-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylsulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylsulfatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arylsulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables arylsulfatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables arylsulfatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arylsulfatase G
    Names
    N-sulfoglucosamine-3-sulfatase
    NP_001159649.1
    NP_001348904.1
    NP_001348906.1
    NP_001348907.1
    NP_082986.3
    XP_006534411.1
    XP_006534412.1
    XP_006534413.1
    XP_017170289.1
    XP_017170292.1
    XP_030102240.1
    XP_030102241.1
    XP_036012927.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166177.1 → NP_001159649.1  arylsulfatase G isoform 2

      See identical proteins and their annotated locations for NP_001159649.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC084731, BY005671, BY095625
      Consensus CDS
      CCDS48971.1
      UniProtKB/Swiss-Prot
      Q3TYD4
      Related
      ENSMUSP00000102307.2, ENSMUST00000106696.2
      Conserved Domains (1) summary
      cl23718
      Location:5 → 146
      ALP_like; alkaline phosphatases and sulfatases

    2. NM_001361975.1 → NP_001348904.1  arylsulfatase G isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL645791
      Consensus CDS
      CCDS25581.1
      UniProtKB/Swiss-Prot
      B1AT67, B1AT68, Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    3. NM_001361977.1 → NP_001348906.1  arylsulfatase G isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL645791
      Conserved Domains (1) summary
      cl23718
      Location:1 → 336
      ALP_like; alkaline phosphatases and sulfatases

    4. NM_001361978.1 → NP_001348907.1  arylsulfatase G isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (4) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL645791
      Conserved Domains (1) summary
      cl23718
      Location:5 → 48
      ALP_like; alkaline phosphatases and sulfatases

    5. NM_028710.3 → NP_082986.3  arylsulfatase G isoform 1 precursor

      See identical proteins and their annotated locations for NP_082986.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AK158726, BC084731
      Consensus CDS
      CCDS25581.1
      UniProtKB/Swiss-Prot
      B1AT67, B1AT68, Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
      Related
      ENSMUSP00000020928.7, ENSMUST00000020928.13
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      109364159..109464156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534349.4 → XP_006534412.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_006534412.1

      UniProtKB/Swiss-Prot
      B1AT67, B1AT68, Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    2. XM_030246381.1 → XP_030102241.1  arylsulfatase G isoform X2

      Conserved Domains (1) summary
      cl23718
      Location:1 → 336
      ALP_like; alkaline phosphatases and sulfatases

    3. XM_006534348.2 → XP_006534411.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_006534411.1

      UniProtKB/Swiss-Prot
      B1AT67, B1AT68, Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    4. XM_017314803.1 → XP_017170292.1  arylsulfatase G isoform X3

      Conserved Domains (1) summary
      cl23718
      Location:35 → 371
      ALP_like; alkaline phosphatases and sulfatases

    5. XM_017314800.3 → XP_017170289.1  arylsulfatase G isoform X1

      UniProtKB/Swiss-Prot
      B1AT67, B1AT68, Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    6. XM_036157034.1 → XP_036012927.1  arylsulfatase G isoform X1

      UniProtKB/Swiss-Prot
      B1AT67, B1AT68, Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
      Related
      ENSMUSP00000102308.2, ENSMUST00000106697.8
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    7. XM_006534350.5 → XP_006534413.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_006534413.1

      UniProtKB/Swiss-Prot
      B1AT67, B1AT68, Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G

    8. XM_030246380.2 → XP_030102240.1  arylsulfatase G isoform X1

      UniProtKB/Swiss-Prot
      B1AT67, B1AT68, Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
      Conserved Domains (1) summary
      cd16161
      Location:35 → 469
      ARSG; arylsulfatase G
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TYD4.1 GenPept UniProtKB/Swiss-Prot:Q3TYD4

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