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Links from Protein

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    wap wings apart [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33131, updated on 2-Nov-2024

    Summary

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    Official Symbol
    wapprovided by FlyBase
    Official Full Name
    wings apartprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266848
    Locus tag
    Dmel_CG14614
    See related
    AllianceGenome:FB:FBgn0266848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    15; 16; 19; 20; 21; 22; BcDNA:GM08142; CG14614; Dmel\CG14614; l(1)20Ab; l(1)A-200; l(1)HM33; l(1)Q217; l(1)Q464; Q217; Q464; riq; Riq; WAP
    Summary
    Enables protein-macromolecule adaptor activity. Involved in several processes, including myoblast development; positive regulation of organ growth; and regulation of signal transduction. Is active in nucleus. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See wap in Genome Data Viewer
    Location:
    20C1-20C1; 1-66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22451445..22455422, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21853281..21857258, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene touch insensitive larva B Neighboring gene Ubiquitin specific protease 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DCAF7 regulates cell proliferation through IRS1-FOXO1 signaling. Frendo-Cumbo S, et al. iScience, 2022 Oct 21. PMID 36248734, Free PMC Article
    2. Hearing in Drosophila requires TilB, a conserved protein associated with ciliary motility. Kavlie RG, et al. Genetics, 2010 May. PMID 20215474, Free PMC Article
    3. Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua. Yang L, et al. Proc Natl Acad Sci U S A, 2016 Sep 20. PMID 27601662, Free PMC Article
    4. DYRK1A and cognition: A lifelong relationship. Arbones ML, et al. Pharmacol Ther, 2019 Feb. PMID 30268771
    5. Characterization of the flamenco region of the Drosophila melanogaster genome. Robert V, et al. Genetics, 2001 Jun. PMID 11404334, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wings apart
    Names
    CG14614-PA
    CG14614-PB
    CG14614-PC
    CG14614-PD
    riquiqui
    section 15
    section 16
    section 19
    section 20
    section 21
    section 22
    wap-PA
    wap-PB
    wap-PC
    wap-PD
    wings-apart

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22451445..22455422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298597.1 → NP_001285526.1  wings apart, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR53
      Conserved Domains (2) summary
      sd00039
      Location:75 → 117
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:19 → 295
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001258869.3 → NP_001245798.1  wings apart, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR53
      Conserved Domains (2) summary
      sd00039
      Location:75 → 117
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:19 → 295
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_134617.5 → NP_608461.1  wings apart, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR53
      Related
      FBpp0077060
      Conserved Domains (2) summary
      sd00039
      Location:75 → 117
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:19 → 295
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001258868.3 → NP_001245797.1  wings apart, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR53
      Conserved Domains (2) summary
      sd00039
      Location:75 → 117
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:19 → 295
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95S63 Q95S63
    Q95T24 Q95T24
    Q9VR53 Q9VR53

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