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    PYR4 pyrimidin 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828392, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PYR4
    Official Full Name
    pyrimidin 4
    Primary source
    TAIR:AT4G22930
    Locus tag
    AT4G22930
    See related
    Araport:AT4G22930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DHOASE; DIHYDROOROTASE; F7H19.110; F7H19_110; pyrimidin 4
    Summary
    Encodes dihydroorotase (PYR4).
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    Genomic context

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    See PYR4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (12018829..12021782)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene FIZZY-related 2 Neighboring gene non-yellowing 1 Neighboring gene Protein kinase superfamily protein Neighboring gene AGAMOUS-like 19 Neighboring gene FAM63A-like protein (DUF544)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of de novo pyrimidine synthesis in solanaceous species. Giermann N, et al. Plant Mol Biol, 2002 Oct. PMID 12369616
    2. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001341566.1
    NM_118422.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dihydroorotase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydroorotase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    pyrimidin 4
    NP_194024.1
    • pyrimidin 4 (PYR4); FUNCTIONS IN: dihydroorotase activity; INVOLVED IN: 'de novo' pyrimidine base biosynthetic process, pyrimidine base biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dihydroorotase, conserved site (InterPro:IPR002195), Dihydroorotase homodimeric type (InterPro:IPR004721), Amidohydrolase 1 (InterPro:IPR006680); Has 3373 Blast hits to 3371 proteins in 1108 species: Archae - 32; Bacteria - 2225; Metazoa - 2; Fungi - 146; Plants - 54; Viruses - 0; Other Eukaryotes - 914 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12018829..12021782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118422.4 → NP_194024.1  pyrimidin 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194024.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04904, Q0WRL0
      UniProtKB/TrEMBL
      A0A178V399, A0A5S9XUY5
      Conserved Domains (1) summary
      PLN02599
      Location:13 → 375
      PLN02599; dihydroorotase

    2. NM_001341566.1 → NP_001327985.1  pyrimidin 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04904, Q0WRL0
      UniProtKB/TrEMBL
      A0A178V399, A0A5S9XUY5
      Conserved Domains (1) summary
      PLN02599
      Location:13 → 375
      PLN02599; dihydroorotase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04904.1

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