L1 major capsid protein L1 [Human papillomavirus 16] - Gene

Summary

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Gene symbol: L1
Gene description: major capsid protein L1
Locus tag: HpV16gp8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Human papillomavirus 16
Lineage: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 9
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Genomic context

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Sequence:: NC_001526.4 (4775..6292)

NC_001526.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001526.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic diversity in L1 ORF of human papillomavirus in women with cervical cancer with and without human immunodeficiency virus in Botswana and Kenya.
Title: Genetic diversity in L1 ORF of human papillomavirus in women with cervical cancer with and without human immunodeficiency virus in Botswana and Kenya.
Human papillomavirus 16 L1 gene methylation as a potential biomarker for predicting anal intraepithelial neoplasia in men who have sex with men (MSM).
Title: Human papillomavirus 16 L1 gene methylation as a potential biomarker for predicting anal intraepithelial neoplasia in men who have sex with men (MSM).
Characterization of major capsid protein (L1) variants of Human papillomavirus type 16 by cervical neoplastic status in Indian women: Phylogenetic and functional analysis.
Title: Characterization of major capsid protein (L1) variants of Human papillomavirus type 16 by cervical neoplastic status in Indian women: Phylogenetic and functional analysis.
Methylation of CpG 5962 in L1 of the human papillomavirus 16 genome as a potential predictive marker for viral persistence: A prospective large cohort study using cervical swab samples.
Title: Methylation of CpG 5962 in L1 of the human papillomavirus 16 genome as a potential predictive marker for viral persistence: A prospective large cohort study using cervical swab samples.
By confocal analysis, it was determined that nuclear entry of assembled L1 is dependent upon the presence of the minor capsid protein, L2, but independent of encapsidated DNA.
Title: Human Papillomavirus 16 Capsids Mediate Nuclear Entry during Infection.
A total of 626 mutation events affecting 83 distinct nucleotides into the five antigenic regions of L1 gene of HPV16 were reported.
Title: HPV16 L1 diversity and its potential impact on the vaccination-induced immunity.
The authors show that stannin interacts with human papillomavirus 16 L1 major capsid protein and impairs the interaction of the L2 minor capsid protein with retromer, which is required for virus trafficking to the trans-Golgi network.
Title: The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry.
Human papillomavirus L1 protein expressed in Escherichia coli self-assembles into virus-like particles that are highly immunogenic.
Title: Human papillomavirus L1 protein expressed in Escherichia coli self-assembles into virus-like particles that are highly immunogenic.
The HPV-16 structures clarify details of capsid architecture for the first time, including variation in L1 major capsid protein conformation and putative location of L2 minor protein.
Title: Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site.
Results show that HPV59 L1-only capsid demonstrates that the C-terminal arm of L1 participates in virus-host interactions and is immunogenic.
Title: The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

misc_difference

Loc: 5378
Loc: 6039-6041
Loc: 6088

General protein information

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Preferred Names: major capsid protein L1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001526.4 Reference assembly

Range

4775..6292

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_041332.2 major capsid protein L1 [Human papillomavirus 16]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O00530, P03101

UniProtKB/TrEMBL

A0A089NDG7, A0A142KD63, A0A159DRT2, A0A161HCQ4, A0A161HLT0, A0A166MA66, A0A3G2LCQ6, Q9WLQ6

Conserved Domains (1) summary

PHA02778
Location:1 → 504

PHA02778; major capsid L1 protein; Provisional