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    Gda guanine deaminase [ Mus musculus (house mouse) ]

    Gene ID: 14544, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gdaprovided by MGI
    Official Full Name
    guanine deaminaseprovided by MGI
    Primary source
    MGI:MGI:95678
    See related
    Ensembl:ENSMUSG00000058624 AllianceGenome:MGI:95678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAH
    Summary
    Enables guanine deaminase activity. Involved in several processes, including deoxyguanosine catabolic process; guanine catabolic process; and purine nucleoside monophosphate catabolic process. Is active in cytosol. Is expressed in several structures, including adrenal gland; brain; and peripheral nervous system ganglion. Orthologous to human GDA (guanine deaminase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 22.6), cortex adult (RPKM 19.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gda in Genome Data Viewer
    Location:
    19 B; 19 14.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (21368671..21450025, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (21391307..21472661, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1562 Neighboring gene STARR-seq mESC enhancer starr_45720 Neighboring gene predicted gene, 45918 Neighboring gene STARR-seq mESC enhancer starr_45722 Neighboring gene VISTA enhancer mm269 Neighboring gene predicted gene, 57661 Neighboring gene zinc finger, AN1-type domain 5 Neighboring gene STARR-seq mESC enhancer starr_45723 Neighboring gene STARR-seq mESC enhancer starr_45724 Neighboring gene STARR-seq mESC enhancer starr_45725 Neighboring gene STARR-seq mESC enhancer starr_45726 Neighboring gene predicted gene 3443 Neighboring gene predicted gene, 38486

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNA sequence of five mouse guanine deaminase (Gda) alleles and mapping to mouse chromosome 19. Giese RD, et al. Genome, 2002 Apr. PMID 11962625
    2. The highest levels of purine catabolic enzymes in mice are present in the proximal small intestine. Mohamedali KA, et al. J Biol Chem, 1993 Nov 5. PMID 8226898
    3. Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. Yuan G, et al. J Biol Chem, 1999 Mar 19. PMID 10075721
    4. Enzymes of purine salvage and catabolism in the mouse preimplantation embryo measured by high performance liquid chromatography. Alexiou M, et al. J Reprod Fertil, 1994 May. PMID 8064675
    5. Proteomics analysis of immuno-precipitated synaptic protein complexes. Klemmer P, et al. J Proteomics, 2009 Feb 15. PMID 19022416

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in allantoin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dGMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deoxyguanosine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in guanine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in guanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in guanine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine deaminase
    Names
    guanase
    guanine aminase
    guanine aminohydrolase
    NP_034396.1
    XP_006526743.1
    XP_017173553.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010266.2 → NP_034396.1  guanine deaminase

      See identical proteins and their annotated locations for NP_034396.1

      Status: VALIDATED

      Source sequence(s)
      AC103947, AK041056, BY250819
      Consensus CDS
      CCDS29698.1
      UniProtKB/Swiss-Prot
      Q9R111
      UniProtKB/TrEMBL
      Q3U0C4, Q548F2, Q71RH5, Q71RH6
      Related
      ENSMUSP00000084882.4, ENSMUST00000087600.10
      Conserved Domains (1) summary
      cd01303
      Location:13 → 444
      GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      21368671..21450025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526680.2 → XP_006526743.1  guanine deaminase isoform X1

      UniProtKB/TrEMBL
      A0A494B982
      Related
      ENSMUSP00000157532.2, ENSMUST00000237823.2
      Conserved Domains (1) summary
      cd01303
      Location:2 → 402
      GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...

    2. XM_017318064.3 → XP_017173553.1  guanine deaminase isoform X2

      UniProtKB/TrEMBL
      A0A494B982, D3YU09
      Related
      ENSMUSP00000112758.2, ENSMUST00000121725.8
      Conserved Domains (1) summary
      cl00281
      Location:1 → 370
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R111.1 GenPept UniProtKB/Swiss-Prot:Q9R111

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